Part of a haplotype Gs286, standalone effect for endometrial cancer is ambiguous. Tightly linked with PROGINS allele.
Some evidence of interaction on caucasian/hispanic patients with 17-alpha-hydroxyprogesterone caproate for reducing recurrent preterm birth detected. [PMID 21600550
]
PROGINS allele and this SNP in particular were found to not be involved in male infertility. [PMID 23934021]
| GWAS snp
|
| PMID
|
[PMID 20547493]
|
| Trait
|
Endometrial cancer
|
| Title
|
Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach.
|
| Risk Allele
|
G
|
| P-val
|
0.40
|
| Odds Ratio
|
1.25 [1.03-1.54]
|
[PMID 23934021] Association of progesterone receptor gene polymorphism with male infertility and clinical outcome of ICSI
[PMID 21600550] Progesterone receptor polymorphisms and clinical response to 17-alpha-hydroxyprogesterone caproate
[PMID 15632380] Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis
]
