rs3746444

minus

Geno	Mag	Summary
(C;C)	2.1	~1.2x increased risk for cancer
(C;T)	2	~1.2x increased risk for cancer
(T;T)	2.1	decreased cancer risk

Reference

GRCh38 38.1/141

Chromosome

20

Position

34990448

Gene	LOC107985393, MIR499A, MIR499B, MYH7B

is a	snp
is	mentioned by
dbSNP	rs3746444
dbSNP (classic)	rs3746444
ClinGen	rs3746444
ebi	rs3746444
HLI	rs3746444
Exac	rs3746444
Gnomad	rs3746444
Varsome	rs3746444
LitVar	rs3746444
Map	rs3746444
PheGenI	rs3746444
Biobank	rs3746444
1000 genomes	rs3746444
hgdp	rs3746444
ensembl	rs3746444
geneview	rs3746444
scholar	rs3746444
google	rs3746444
pharmgkb	rs3746444
gwascentral	rs3746444
openSNP	rs3746444
23andMe	rs3746444
SNPshot	rs3746444
SNPdbe	rs3746444
MSV3d	rs3746444
GWAS Ctlg	rs3746444

GMAF

0.1814

Max Magnitude

2.1

[PMID 18634034] microRNA 1,009 breast cancer cases and 1,093 controls in a population of Chinese women

rs3746444 in hsa-mir-499 A>G OR 1.25; 95% CI, 1.02-1.51

[PMID 19293314] A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptibility of Lung Cancer in Chinese.

[PMID 19514064] Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population

[PMID 19847796] Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases

[PMID 20488170] Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy

[PMID 20549817 ] Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck

[PMID 20842445] Genetic variation in microRNA genes and prostate cancer risk in North Indian population

[PMID 20848167] Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis

[PMID 21073609] Association Between Common Genetic Variants in Pre-microRNAs and Gastric Cancer Risk in Japanese Population

[PMID 21524676] Genetic study of two single nucleotide polymorphisms within corresponding microRNAs and susceptibility to tuberculosis in a Chinese Tibetan and Han population

[PMID 21861697 ] Association Between Two Genetic Variants in miRNA and Primary Liver Cancer Risk in the Chinese Population

[PMID 21565178] Association between SNPs in pre-miRNA and risk of chronic obstructive pulmonary disease

[PMID 22451023] IRAK1 rs3027898 C/A polymorphism is associated with risk of rheumatoid arthritis

[PMID 18521189 ] Genetic variants of miRNA sequences and non-small cell lung cancer survival.

[PMID 19458495 ] Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.

[PMID 19617315 ] SNPs in human miRNA genes affect biogenesis and function.

[PMID 19881472] Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis.

[PMID 20428464 ] MicroRNA polymorphisms: a giant leap towards personalized medicine.

[PMID 20520619] Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population.

[PMID 20845080] Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus.

[PMID 21181275] Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population.

[PMID 21319225] Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma.

[PMID 21345130] Investigative role of pre-microRNAs in bladder cancer patients: a case-control study in North India.

[PMID 21663520] Association between single-nucleotide polymorphisms in pre-miRNAs and the risk of asthma in a Chinese population.

[PMID 21713406] Association between two single nucleotide polymorphisms at corresponding microRNA and schizophrenia in a Chinese population.

[PMID 21902575] Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers.

[PMID 22019503] Association of polymorphisms in pre-miRNA with inflammatory biomarkers in rheumatoid arthritis in the Chinese Han population.

[PMID 22159951] Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease.

[PMID 22311030] Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population.

[PMID 23138379] Association of pre-miRNA-146a rs2910164 and pre‑miRNA-499 rs3746444 polymorphisms and susceptibility to rheumatoid arthritis

[PMID 23236400 ] Hsa-miR-499 rs3746444 Polymorphism Contributes to Cancer Risk: A Meta-Analysis of 12 Studies

[PMID 23271127] The association between common genetic variant of microRNA-499 and cancer susceptibility: a meta-analysis

[PMID 23437296 ] The Association between Two Common Polymorphisms in MicroRNAs and Hepatocellular Carcinoma Risk in Asian Population

[PMID 23470291] Association between Genetic Variants in Pre-MicroRNAs and Survival of Early-Stage NSCLC

[PMID 23219900 ] Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx

[PMID 23613771 ] Polymorphisms of microRNA Sequences or Binding Sites and Lung Cancer: A Meta-Analysis and Systematic Review

[PMID 23679271] Positive Association Between miR-499A>G and Hepatocellular Carcinoma Risk in a Chinese Population

[PMID 23728616] Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population

[PMID 23725137] Association of mir-499 and mir-149 Polymorphisms with Cancer Risk in the Chinese Population: Evidence from Published Studies

[PMID 23888320] A functional polymorphism in the miR-146a gene is associated with the risk of childhood acute lymphoblastic leukemia: a preliminary report

[PMID 24085457] An A/G polymorphism rs3746444 in miR-499 is associated with increased cancer risk: a meta-analysis

[PMID 24102488] Meta-analysis of pre-miRNA polymorphisms association with susceptibility to autoimmune diseases

[PMID 24107911] Association of the hsa-mir-499 (rs3746444) Polymorphisms with Gastric Cancer Risk in the Chinese Population

[PMID 24136745] Association between microRNA genetic variants and susceptibility to colorectal cancer in Chinese population

[PMID 23791656] Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis

[PMID 24194751 ] Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation

[PMID 24254303] Two functional polymorphisms in microRNAs and lung cancer risk: a meta-analysis

[PMID 24258110] Quantitative assessment of the association between microRNA-499 rs3746444 A/G polymorphism and cancer risk

[PMID 24301908] miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population

[PMID 24327058] MicroRNA-499 rs3746444 Polymorphism and Autoimmune Diseases Risk: A Meta-Analysis

[PMID 24413317 ] MicroRNA sequence polymorphisms and the risk of different types of cancer

[PMID 24447667] A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression

[PMID 24568449] Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility

[PMID 24618566] Non-coding RNAs-related polymorphisms in pediatric acute lymphoblastic leukemia susceptibility

[PMID 22659075] Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population.

[PMID 22903035] The association between hsa-miR-499 T>C polymorphism and cancer risk: a meta-analysis.

[PMID 22922391] Hsa-miR-499 polymorphism (rs3746444) and cancer risk: a meta-analysis of 17 case-control studies.

[PMID 22970328 ] Association of microRNA-499 rs3746444 polymorphism with cancer risk: evidence from 7188 cases and 8548 controls.

[PMID 23001871] Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with gastric cancer risk and survival in the Korean population.

[PMID 23053947] miR-499 rs3746444 polymorphism is associated with cancer development among Asians and related to breast cancer susceptibility.

[PMID 23292097] Effects of common polymorphisms rs2910164 in miR-146a and rs3746444 in miR-499 on cancer susceptibility: a meta-analysis.

[PMID 23593385 ] Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk.

[PMID 23731641] Association of microRNAs genes polymorphisms with rheumatoid arthritis in Egyptian female patients.

[PMID 24854593 ] Identification of miR-423 and miR-499 Polymorphisms on Affecting the Risk of Hepatocellular Carcinoma in a Large-Scale Population

[PMID 24039706 ] The associations of single nucleotide polymorphisms in miR-146a, miR-196a and miR-499 with breast cancer susceptibility

[PMID 24922658] Genetic Polymorphism of miR-196a as a Prognostic Biomarker for Early Breast Cancer

[PMID 24978643] Genetic variants of MicroRNA-related genes in susceptibility and prognosis of end-stage renal disease and renal allograft outcome among north Indians

[PMID 25074528] rs3746444 Polymorphism and Susceptibility to Hepatocellular Carcinoma: Evidence from Published Studies

[PMID 25218914] Comprehensive Review of Genetic Association Studies and Meta-analysis on miRNA polymorphisms and rheumatoid arthritis and systemic lupus erythematosus susceptibility

[PMID 24681820] Genetic variations in microRNAs and the risk and survival of renal cell cancer

[PMID 25374621 ] Common genetic variants in pre-microRNAs and risk of breast cancer in the North Indian population

[PMID 25795117] Comprehensive assessment of the association between miRNA polymorphisms and gastric cancer risk

[PMID 25861865] Polymorphism in mature microRNA-608 sequence is associated with an increased risk of nasopharyngeal carcinoma

[PMID 25901206 ] Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease

[PMID 25176041 ] High-resolution melting analysis reveals genetic polymorphisms in microRNAs confer hepatocellular carcinoma risk in Chinese patients

[PMID 26053525] Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease

[PMID 26112096] Assessment of association between genetic variants in microRNA genes hsa-miR-499, hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population

[PMID 26305248 ] Variants of MicroRNA Genes: Gender-Specific Associations with Multiple Sclerosis Risk and Severity

[PMID 26458899 ] Common genetic polymorphisms in pre-microRNAs and risk of bladder cancer

[PMID 26518769] Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population

[PMID 26597478] Association between microRNA-499 polymorphism and gastric cancer risk in Chinese population

[PMID 26608782 ] Association Between Single-Nucleotide Polymorphism (SNP) in miR-146a, miR-196a2, and miR-499 and Risk of Ischemic Stroke: A Meta-Analysis.

[PMID 26886638 ] The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study.

[PMID 27509977] Combined Genotype Analyses of Precursor miRNA196a2 and 499a Variants with Hepatic and Renal Cancer Susceptibility a Preliminary Study.

[PMID 27813602] Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population.

[PMID 27888002] Polymorphisms in MIR499A and MIR125A gene are associated with autoimmune thyroid diseases.

[PMID 28301487 ] Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs.

[PMID 28886711 ] Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma.

[PMID 28922434] Association of microRNA Polymorphisms with the Risk of Gastric Cancer in a Romanian Population.

[PMID 29108839] Association between a MIR499A polymorphism and diabetic neuropathy in type 2 diabetes.

[PMID 30084801] Association of a MiR-499 SNP and risk of congenital heart disease in a Chinese population.

[PMID 30229913] Association of the genetic polymorphisms in immunoinflammatory microRNAs with risk of ischemic stroke and subtypes in an Iranian population.

[PMID 30864695] Single nucleotide polymorphism rs3746444 in miR‑499a affects susceptibility to non‑small cell lung carcinoma by regulating the expression of CD200.

[PMID 30872409 ] Impacts of Single Nucleotide Polymorphisms in three MicroRNAs (miR-146a, miR-196a2 and miR-499) on Susceptibility to Cervical Cancer among Indian Women.

[PMID 31496728 ] Association of miRNA-499 rs3746444 A>G variants with adenocarcinoma of esophagogastric junction (AEG) risk and lymph node status.

[PMID 33145433 ] MicroRNA-499 rs3746444 polymorphism in Egyptian children with biliary atresia.

[PMID 33230439 ] miR-499 rs3746444 and miR-196a-2 rs11614913 Are Associated with the Risk of Glioma, but Not the Prognosis.

[PMID 33319237 ] The correlation of microRNA-499 rs3746444 T>C locus with the susceptibility of gastric cancer: From a case-control study to a meta-analysis.