|(A;A)||Associated with ADHD|
|(C;C)||Associated with Schizophrenia|
[PMID 19132710] SNPs nominally associated with schizophrenia (rs3787283, rs3746544) were the same as those previously demonstrated to be associated with ADHD but with the opposite alleles, allowing the intriguing hypothesis that genetic variation at SNAP25 may be differentially associated with both schizophrenia and ADHD
When comparing pooled results of multiple ADHD studies, only rs3746544(A) was found to have a significant association (p=0.028) with slightly increased risk (OR 1.15 at 95%) of ADHD. [PMID 19721846] Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants
[PMID 17325713] Support for the MnlI polymorphism of SNAP25; a Korean ADHD case-control study.
[PMID 17455213] Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorder.
[PMID 12660803] Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder.
[PMID 16380908] Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder.
[PMID 21557260] Haplotyping of putative microRNA-binding sites in the SNAP-25 gene.
[PMID 21996783] Role of SNAP25 explored in eastern Indian attention deficit hyperactivity disorder probands.
[PMID 23872233] The relationship between the presence of ADHD and certain candidate gene polymorphisms in a Turkish sample
[PMID 24164654] Genetic variants of synaptic vesicle and presynaptic plasma membrane proteins in idiopathic generalized epilepsy
[PMID 22940547] Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes.
[PMID 23593184] DNA variation in the SNAP25 gene confers risk to ADHD and is associated with reduced expression in prefrontal cortex.
[PMID 25054019] Meta-analyses of 10 polymorphisms associated with the risk of schizophrenia
[PMID 25229170] Association of SNAP-25, SLC6A2, and LPHN3 With OROS Methylphenidate Treatment Response in Attention-Deficit/Hyperactivity Disorder
[PMID 25650683] SNAP25 is associated with schizophrenia and major depressive disorder in the Han Chinese population
[PMID 27380186] Two SNAP-25 genetic variants in the binding site of multiple microRNAs and susceptibility of ADHD: A meta-analysis.
[PMID 27888397] Synaptosome-Associated Protein 25 (SNAP25) Gene Association Analysis Revealed Risk Variants for ASD, in Iranian Population.
[PMID 31653583] Relationship of SNAP25 variants with schizophrenia and antipsychotic-induced weight change in large-scale schizophrenia patients.