rs3754777
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.5 | slightly higher blood pressure if Caucasian |
| (A;G) | slightly higher blood pressure if Caucasian | |
| (G;G) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 2 |
| Position | 168159404 |
| Gene | STK39 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3754777 |
| dbSNP (classic) | rs3754777 |
| ClinGen | rs3754777 |
| ebi | rs3754777 |
| HLI | rs3754777 |
| Exac | rs3754777 |
| Gnomad | rs3754777 |
| Varsome | rs3754777 |
| LitVar | rs3754777 |
| Map | rs3754777 |
| PheGenI | rs3754777 |
| Biobank | rs3754777 |
| 1000 genomes | rs3754777 |
| hgdp | rs3754777 |
| ensembl | rs3754777 |
| geneview | rs3754777 |
| scholar | rs3754777 |
| rs3754777 | |
| pharmgkb | rs3754777 |
| gwascentral | rs3754777 |
| openSNP | rs3754777 |
| 23andMe | rs3754777 |
| SNPshot | rs3754777 |
| SNPdbe | rs3754777 |
| MSV3d | rs3754777 |
| GWAS Ctlg | rs3754777 |
| GMAF | 0.1942 |
| Max Magnitude | 1.5 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs3754777 is a SNP in the serine threonine kinase 39 STK39 gene.
A study of ~1,000 Amish originally identified rs3754777 and another SNP also in the STK39 gene, rs6749447, as being significantly associated with hypertension. This association was then found to also hold in patient data analyzed from the Framingham Heart Study and the Diabetes Genetics Initiative. On average, each minor allele, in this case rs3754777(A), is associated with 2.0 mmHg higher systolic blood pressure and a 1.0 mm Hg higher diastolic pressure.10.1073/pnas.0808358106
[PMID 20003416
] STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression
[PMID 20889219] STK39 is an independent risk factor for male hypertension in Han Chinese
[PMID 19114657] From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.
[PMID 21228780] Novel genetic variations associated with salt sensitivity in the Korean population.
High Blood Pressure (Hypertension)
[PMID 23408757] Association between Serine/Threonine Kinase 39 Gene Polymorphism, Hypertension, and Other Cardiovascular Risk Factors in Koreans
[PMID 23591986] Influence of obesity on association between genetic variants identified by genome-wide association studies and hypertension risk in Chinese children.
