rs3764650
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | Late onset? |
| (G;T) | 0 | Late onset? |
| (T;T) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 19 |
| Position | 1046521 |
| Gene | ABCA7 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3764650 |
| dbSNP (classic) | rs3764650 |
| ClinGen | rs3764650 |
| ebi | rs3764650 |
| HLI | rs3764650 |
| Exac | rs3764650 |
| Gnomad | rs3764650 |
| Varsome | rs3764650 |
| LitVar | rs3764650 |
| Map | rs3764650 |
| PheGenI | rs3764650 |
| Biobank | rs3764650 |
| 1000 genomes | rs3764650 |
| hgdp | rs3764650 |
| ensembl | rs3764650 |
| geneview | rs3764650 |
| scholar | rs3764650 |
| rs3764650 | |
| pharmgkb | rs3764650 |
| gwascentral | rs3764650 |
| openSNP | rs3764650 |
| 23andMe | rs3764650 |
| SNPshot | rs3764650 |
| SNPdbe | rs3764650 |
| MSV3d | rs3764650 |
| GWAS Ctlg | rs3764650 |
| GMAF | 0.1997 |
| Max Magnitude | 0 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
Alzheimer's disease associated, based on large 2011 study 10.1038/ng.803
"The minor allele of Rs3764650 in ABCA7 was associated with a later age at onset and shorter disease course" according to http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511432/
| GWAS snp | |
|---|---|
| PMID | [PMID 21460840 ]
|
| Trait | |
| Title | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease |
| Risk Allele | |
| P-val | 5E-17 |
| Odds Ratio | 1.2300 [1.18-1.30] |
[PMID 23419238] Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms
[PMID 23226438] Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains
[PMID 23836404] Genetic Susceptibility for Alzheimer Disease Neuritic Plaque Pathology
[PMID 24141082] ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status
[PMID 23180304] Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease.
[PMID 23669301] Interaction between two cholesterol metabolism genes influences memory: findings from the Wisconsin Registry for Alzheimer's Prevention.
[PMID 25189118] Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease
[PMID 26141617] Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study
[PMID 27103528] Association of genetic risk factors with cognitive decline: the PATH through life project.
