rs3768716

increases the odds of aggressive neuroblastoma

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(A;A)	0	normal
(A;G)		1.7x higher risk of aggressive neuroblastoma
(G;G)		2.8x higher risk of aggressive neuroblastoma

Reference

GRCh38 38.1/141

Chromosome

2

Position

214771070

Gene

BARD1

is a	snp
is	mentioned by
dbSNP	rs3768716
dbSNP (classic)	rs3768716
ClinGen	rs3768716
ebi	rs3768716
HLI	rs3768716
Exac	rs3768716
Gnomad	rs3768716
Varsome	rs3768716
LitVar	rs3768716
Map	rs3768716
PheGenI	rs3768716
Biobank	rs3768716
1000 genomes	rs3768716
hgdp	rs3768716
ensembl	rs3768716
geneview	rs3768716
scholar	rs3768716
google	rs3768716
pharmgkb	rs3768716
gwascentral	rs3768716
openSNP	rs3768716
23andMe	rs3768716
SNPshot	rs3768716
SNPdbe	rs3768716
MSV3d	rs3768716
GWAS Ctlg	rs3768716

GMAF

0.1442

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

[PMID 19412175] Common variations in BARD1 influence susceptibility to high-risk neuroblastoma

23andMe blog Each copy of a G at this SNP increases the odds of aggressive neuroblastoma by 1.68 times.

allelic odds ratio of 1.68 (p = 2.74 x 10(-16))

OMIM	256700
Desc	NEUROBLASTOMA
Variant
Related	also

GWAS snp
PMID	[PMID 21124317]
Trait
Title	Integrative genomics identifies LMO1 as a neuroblastoma oncogene
Risk Allele	C
P-val	5E-13
Odds Ratio	1.3860 [NR]

OMIM	613016
Desc
Variant
Related	also

[PMID 18463370] Chromosome 6p22 locus associated with clinically aggressive neuroblastoma.

[PMID 31258718] Functional Polymorphisms in BARD1 Association with Neuroblastoma in a regional Han Chinese Population.