rs3789243
| Orientation | minus |
| Stabilized | minus |
| Make rs3789243(C;C) |
| Make rs3789243(C;T) |
| Make rs3789243(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 7 |
| Position | 87591570 |
| Gene | ABCB1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3789243 |
| dbSNP (classic) | rs3789243 |
| ClinGen | rs3789243 |
| ebi | rs3789243 |
| HLI | rs3789243 |
| Exac | rs3789243 |
| Gnomad | rs3789243 |
| Varsome | rs3789243 |
| LitVar | rs3789243 |
| Map | rs3789243 |
| PheGenI | rs3789243 |
| Biobank | rs3789243 |
| 1000 genomes | rs3789243 |
| hgdp | rs3789243 |
| ensembl | rs3789243 |
| geneview | rs3789243 |
| scholar | rs3789243 |
| rs3789243 | |
| pharmgkb | rs3789243 |
| gwascentral | rs3789243 |
| openSNP | rs3789243 |
| 23andMe | rs3789243 |
| SNPshot | rs3789243 |
| SNPdbe | rs3789243 |
| MSV3d | rs3789243 |
| GWAS Ctlg | rs3789243 |
| GMAF | 0.4807 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
A Danish case-control study comprising 373 Crohn's disease and 541 ulcerative colitis patients (and 796 healthy controls) concluded that carriers of the homozygous COX-2 and MDR1 intron 3 variant (rs3789243) had a relatively high risk of CD, odds ratio (95% CI) (OR (95% CI))=2.86 ((1.34-5.88) p=0.006) and 1.39 ((0.99-1.92) p=0.054), respectively, and for UC of 2.63 ((1.33-5.26) p=0.005) and 1.28 ((0.96-1.51) p=0.093), respectively, assuming complete dominance.[PMID 18819034]
[PMID 19450124] Gene-wide tagging study of association between ABCB1 polymorphisms and multidrug resistance in epilepsy in Han Chinese
[PMID 19685447] Genetic analysis of MDR1 and inflammatory bowel disease reveals protective effect of heterozygous variants for ulcerative colitis
[PMID 22176633] ABCB1/MDR1 polymorphism and colorectal cancer risk: a meta-analysis of case-control studies
[PMID 15197162
] Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene.
[PMID 16434479] ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach.
[PMID 17828778] Role of the PXR gene locus in inflammatory bowel diseases.
[PMID 18424454] ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence.
[PMID 19250544] The multidrug resistance 1 (MDR1) gene polymorphism G-rs3789243-A is not associated with disease susceptibility in Norwegian patients with colorectal adenoma and colorectal cancer; a case control study.
[PMID 19930591] Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study.
[PMID 21530324] Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy.
[PMID 23279665] ABCB1/MDR1 gene polymorphism and colorectal cancer risk: a meta-analysis of case-control studies
