rs3865444
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | common/normal |
| (G;T) | 1.5 | slight reduction in risk for Alzheimer's disease |
| (T;T) | 1.6 | slight reduction in risk for Alzheimer's disease |
| Reference | GRCh38 38.1/141 |
| Chromosome | 19 |
| Position | 51224706 |
| Gene | CD33 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3865444 |
| dbSNP (classic) | rs3865444 |
| ClinGen | rs3865444 |
| ebi | rs3865444 |
| HLI | rs3865444 |
| Exac | rs3865444 |
| Gnomad | rs3865444 |
| Varsome | rs3865444 |
| LitVar | rs3865444 |
| Map | rs3865444 |
| PheGenI | rs3865444 |
| Biobank | rs3865444 |
| 1000 genomes | rs3865444 |
| hgdp | rs3865444 |
| ensembl | rs3865444 |
| geneview | rs3865444 |
| scholar | rs3865444 |
| rs3865444 | |
| pharmgkb | rs3865444 |
| gwascentral | rs3865444 |
| openSNP | rs3865444 |
| 23andMe | rs3865444 |
| SNPshot | rs3865444 |
| SNPdbe | rs3865444 |
| MSV3d | rs3865444 |
| GWAS Ctlg | rs3865444 |
| GMAF | 0.2378 |
| Max Magnitude | 1.6 |
The less common allele for this SNP, rs3865444(T), is associated with a slight decrease in risk for Alzheimer's disease, on the order of 0.9x (i.e. a 10% decrease in risk). One visualization of such studies is available here on the AlzGene website.
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
Alzheimer's disease associated, based on large 2011 study 10.1038/ng.801
[PMID 21460841
] Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
[PMID 22382309] The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer's disease.
[PMID 23623698] Alzheimer's Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
[PMID 23946390] CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing
[PMID 23708142] CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
[PMID 23232270] Association of GWAS-linked loci with late-onset Alzheimer's disease in a northern Han Chinese population.
| GWAS snp | |
|---|---|
| PMID | [PMID 24162737]
|
| Trait | Alzheimer's disease (late onset) |
| Title | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. |
| Risk Allele | C |
| P-val | 3E-6 |
| Odds Ratio | 1.06 [1.04-1.1] |
[PMID 24788522] Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity
[PMID 25670335] Association of Alzheimer's disease GWAS loci with MRI markers of brain aging
[PMID 25762156] Genetics of CD33 in Alzheimer's Disease and Acute Myeloid Leukemia
[PMID 26455864] Association of CD33 and MS4A cluster variants with Alzheimer's disease in East Asian Populations
[PMID 26680604] Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.
[PMID 29872490] Genome-wide significant risk factors on chromosome 19 and the APOE locus.
[PMID 32333488] Association of CD33 rs3865444:C˃A polymorphism with a reduced risk of late-onset Alzheimer's disease in Slovaks is limited to subjects carrying the APOE ε4 allele.
