rs3918396
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | normal | |
| (A;G) | normal | |
| (G;G) | if a smoker, somewhat more likely to develop COPD |
| Reference | GRCh38 38.1/142 |
| Chromosome | 20 |
| Position | 3671118 |
| Gene | ADAM33 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3918396 |
| dbSNP (classic) | rs3918396 |
| ClinGen | rs3918396 |
| ebi | rs3918396 |
| HLI | rs3918396 |
| Exac | rs3918396 |
| Gnomad | rs3918396 |
| Varsome | rs3918396 |
| LitVar | rs3918396 |
| Map | rs3918396 |
| PheGenI | rs3918396 |
| Biobank | rs3918396 |
| 1000 genomes | rs3918396 |
| hgdp | rs3918396 |
| ensembl | rs3918396 |
| geneview | rs3918396 |
| scholar | rs3918396 |
| rs3918396 | |
| pharmgkb | rs3918396 |
| gwascentral | rs3918396 |
| openSNP | rs3918396 |
| 23andMe | rs3918396 |
| SNPshot | rs3918396 |
| SNPdbe | rs3918396 |
| MSV3d | rs3918396 |
| GWAS Ctlg | rs3918396 |
| GMAF | 0.04821 |
| Max Magnitude | 0 |
rs3918396, also known as Ile710Val or S-1, is a SNP in the ADAM metallopeptidase domain 33 ADAM33 gene.
A study of ~600 non-Hispanic white males who smoked concluded that rs3918396(G;G) carriers, i.e. those homozygous for the most common allele, were more likely (p< 0.0026, after Bonferroni correction) to develop chronic obstructive pulmonary disease (COPD) than carriers of one or two rs3918396(A) alleles.10.1186/1465-9921-10-21
[PMID 19236319] Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness
[PMID 12695330
] Exo-proofreading, a versatile SNP scoring technology.
[PMID 16784537] The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations.
[PMID 17878941] ADAM33, a new candidate for psoriasis susceptibility.
[PMID 18778489] Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population.
[PMID 19284602] Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers.
[PMID 23245479] The association between the IL-4, ADRβ2 and ADAM 33 gene polymorphisms and asthma in the Taiwanese population
[PMID 22871616] T1 and T2 ADAM33 single nucleotide polymorphisms and the risk of childhood asthma in a Saudi Arabian population: a pilot study.
[PMID 23380143] A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: a meta-analysis.
[PMID 25691950] Association of ADAM33 gene polymorphisms with allergic asthma
