rs41291556
From SNPedia
| Clopidogrel (Plavix®) |
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 3 | CYP2C19*8 homozygote |
| (C;T) | 2 | carrier of one CYP2C19*8 allele, considered a "slow metabolizer" |
| (T;T) | 0 | normal |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 94775416 |
| Gene | CYP2C19 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs41291556 |
| dbSNP (classic) | rs41291556 |
| ClinGen | rs41291556 |
| ebi | rs41291556 |
| HLI | rs41291556 |
| Exac | rs41291556 |
| Gnomad | rs41291556 |
| Varsome | rs41291556 |
| LitVar | rs41291556 |
| Map | rs41291556 |
| PheGenI | rs41291556 |
| Biobank | rs41291556 |
| 1000 genomes | rs41291556 |
| hgdp | rs41291556 |
| ensembl | rs41291556 |
| geneview | rs41291556 |
| scholar | rs41291556 |
| rs41291556 | |
| pharmgkb | rs41291556 |
| gwascentral | rs41291556 |
| openSNP | rs41291556 |
| 23andMe | rs41291556 |
| SNPshot | rs41291556 |
| SNPdbe | rs41291556 |
| MSV3d | rs41291556 |
| GWAS Ctlg | rs41291556 |
| GMAF | 0.001837 |
| Max Magnitude | 3 |
| This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
|
Defines the CYP2C19 variant known as CYP2C19*8.
Carriers of the rs41291556(C) allele may have decreased activity and poor metabolizer (PM) phenotype. This variant is associated with a dramatic (approximately 90% and 70%) reduction in the metabolism of S-mephenytoin and tolbutamide in vitro.[PMID 10411572]
| ClinVar | |
|---|---|
| Risk | Rs41291556(C;C) |
| Alt | Rs41291556(C;C) |
| Reference | Rs41291556(T;T) |
| Significance | Other |
| Disease | not provided |
| Variation | info |
| Gene | CYP2C19 |
| CLNDBN | not provided |
| Reversed | 0 |
| HGVS | NC_000010.10:g.96535173T>C |
| CLNSRC | |
| CLNACC | RCV000394401.1, |
