rs4140564

minus

Geno	Mag	Summary
(T;T)	0	common in complete genomics

Make rs4140564(C;C)

Make rs4140564(C;T)

Reference

GRCh38 38.1/141

Chromosome

1

Position

186755871

is a	snp
is	mentioned by
dbSNP	rs4140564
dbSNP (classic)	rs4140564
ClinGen	rs4140564
ebi	rs4140564
HLI	rs4140564
Exac	rs4140564
Gnomad	rs4140564
Varsome	rs4140564
LitVar	rs4140564
Map	rs4140564
PheGenI	rs4140564
Biobank	rs4140564
1000 genomes	rs4140564
hgdp	rs4140564
ensembl	rs4140564
geneview	rs4140564
scholar	rs4140564
google	rs4140564
pharmgkb	rs4140564
gwascentral	rs4140564
openSNP	rs4140564
23andMe	rs4140564
SNPshot	rs4140564
SNPdbe	rs4140564
MSV3d	rs4140564
GWAS Ctlg	rs4140564

GMAF

0.04408

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

rs4140564, a SNP on chromosome 1 near the PTGS2 and PLA2G4A genes, has been associated with knee osteoarthritis.

A study of 255 British patients, replicated subsequently in ~2,000 UK, Dutch and US patients, found that rs4140564 was associated with knee osteoarthritis in all populations studied with an overall odds ratio = 1.55, CI: 1.30-1.85, p < 6.9 x 10e-7.[PMID 18471798 ]

GWAS
SNP	rs4140564
PubMedID	[PMID 18471798 ]
Condition	Knee osteoarthritis
Gene	PTGS2, PLA2G4A
Risk Allele
pValue	3.00E-006
OR	1.59
95% CI	1.31-1.94