Have questions? Visit https://www.reddit.com/r/SNPedia


From SNPedia
one of 2 snps relevant to classifying APOE genotype
Is agenotype
Geno Mag Summary
(C;C) 1.2 one of 2 snps relevant to classifying APOE genotype
(C;T) >3x increased risk for Alzheimer's; 1.4x increased risk for heart disease
(T;T) 0 common

One of 2 snps which is necessary to identify ApoE4.

rs429358(C;C) individuals have an increased risk of developing Alzheimer's disease [PMID 15956169].

APOE4 differences only affect the brain after age 60. The memory changes that occur from 20 to 60 do not seem to be connected to APOE4 at all. [1] [2]

Patients with Alzheimer's disease who have at least one ApoE4 allele were found to benefit from a therapy that was ineffective in those who lacked [3]

Inheritance of the rs1799724(T) allele (a variant in another gene, TNF) appears to synergistically increase the risk of Alzheimer's in APOE4 carriers and is associated with altered CSF Abeta42 levels [PMID 15895461]

[PMID 17192785] The researchers found that on testing DNA samples from 1,086 well-characterized Alzheimer's disease cases, a single SNP (rs4420638) lying 14 kb distal to the ApoE locus has a powerful association with late-onset AD (corrected p value was 5.3 x 10 e-34). No other SNP showed as robust an association. The authors estimated that people with two ApoE4 copies, such as a person with the rs429358(C;C) genotype, have a 25-fold increased risk for developing the disease compared to ApoE3/ApoE3 carriers. [4]