rs4320932
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | normal |
| (A;G) | 1.2 | 0.87x decreased risk for ovarian cancer |
| (G;G) | 1.4 | 0.74x decreased risk for ovarian cancer |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 2150371 |
| Gene | IGF2, INS-IGF2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4320932 |
| dbSNP (classic) | rs4320932 |
| ClinGen | rs4320932 |
| ebi | rs4320932 |
| HLI | rs4320932 |
| Exac | rs4320932 |
| Gnomad | rs4320932 |
| Varsome | rs4320932 |
| LitVar | rs4320932 |
| Map | rs4320932 |
| PheGenI | rs4320932 |
| Biobank | rs4320932 |
| 1000 genomes | rs4320932 |
| hgdp | rs4320932 |
| ensembl | rs4320932 |
| geneview | rs4320932 |
| scholar | rs4320932 |
| rs4320932 | |
| pharmgkb | rs4320932 |
| gwascentral | rs4320932 |
| openSNP | rs4320932 |
| 23andMe | rs4320932 |
| SNPshot | rs4320932 |
| SNPdbe | rs4320932 |
| MSV3d | rs4320932 |
| GWAS Ctlg | rs4320932 |
| GMAF | 0.258 |
| Max Magnitude | 1.4 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs4320932 is a SNP in the IF2 insulin-like growth factor 2 gene.
A study totaling ~5,000 non-Hispanic white patients with ovarian cancer found a 13% decreased risk of ovarian cancer per copy of the rs4320932(G) allele carried (CI: 0.81-0.93, P-trend=7.4 × 10e-5).[PMID 21422097
]
Associated with schizophrenia in a study of Croatians. Due to the limited number (~100 patients) and diversity of the studied population, more study is needed to confirm any link. The G allele was associated with an increased risk of schizophrenia with P < 0.001.[PMID 19673036]
Small size study [PMID 23677070] with 212 cases linked the G allele earlier found protective against ovarian cancer increasing relapse by 3.05 (95% confidence interval CI: 1.47–6.37, P-trend 2*10e-4) and mortality 3.28 (95% CI: 1.64–6.57, P-trend 6*10e-5).
[PMID 17980034] Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool 'CubeX'.
[PMID 19673036] Association of Tagging Single Nucleotide Polymorphisms on 8 Candidate Genes in Dopaminergic Pathway with Schizophrenia in Croatian Population
[PMID 19956101] Overview of the Rapid Response data.
| GWAS snp | |
|---|---|
| PMID | [PMID 21422097]
|
| Trait | Ovarian cancer |
| Title | Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk. |
| Risk Allele | G |
| P-val | 7.4E-5 |
| Odds Ratio | 0.87 [0.81-0.93] |
[PMID 22113349] Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.
[PMID 22567146] Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes
[PMID 23677070] An Insulin-like Growth Factor-II Intronic Variant Affects Local DNA Conformation and Ovarian Cancer Survival
[PMID 32314747] Insulin-Like Growth Factor 1 (IGF1) Pathway Member Polymorphisms Are Associated with Risk and Prognosis of Chondrosarcoma.
