rs4349633

Orientation

plus

Stabilized

plus

Make rs4349633(A;A)

Make rs4349633(A;G)

Make rs4349633(G;G)

Reference

GRCh38 38.1/141

Chromosome

4

Position

41483195

Gene

LIMCH1

is a	snp
is	mentioned by
dbSNP	rs4349633
dbSNP (classic)	rs4349633
ClinGen	rs4349633
ebi	rs4349633
HLI	rs4349633
Exac	rs4349633
Gnomad	rs4349633
Varsome	rs4349633
LitVar	rs4349633
Map	rs4349633
PheGenI	rs4349633
Biobank	rs4349633
1000 genomes	rs4349633
hgdp	rs4349633
ensembl	rs4349633
geneview	rs4349633
scholar	rs4349633
google	rs4349633
pharmgkb	rs4349633
gwascentral	rs4349633
openSNP	rs4349633
23andMe	rs4349633
SNPshot	rs4349633
SNPdbe	rs4349633
MSV3d	rs4349633
GWAS Ctlg	rs4349633

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

Region with strongest linkage for ability to discriminate pitch found in study of 767 Finnish individuals belonging in 76 families [PMID 24614497], involved in musical aptitude. Posterior Probability of Linkage given as 86% to trait Carl Seashore's subtest of pitch (SP).

Located next to the region harboring the protocadherin 7 gene, PCDH7 which has been suggested to play a role in cochlear and amygdaloid complexes. This SNP is in LIMCH1 LIM and calponin homology domains 1 gene, which is thought to be unlikely to be responsible, probably a combination of SNP's frequently inherited with it are involved. The study suggests rs13146789 in PCDH7 as one likely causal variant.

Publications

[PMID 24614497] A genome-wide linkage and association study of musical aptitude identifies loci containing genes related to inner ear development and neurocognitive functions.