rs4359
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | faster responder | |
| (C;T) | slower responder | |
| (T;T) | faster responder |
| Reference | GRCh38 38.1/141 |
| Chromosome | 17 |
| Position | 63494982 |
| Gene | ACE |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4359 |
| dbSNP (classic) | rs4359 |
| ClinGen | rs4359 |
| ebi | rs4359 |
| HLI | rs4359 |
| Exac | rs4359 |
| Gnomad | rs4359 |
| Varsome | rs4359 |
| LitVar | rs4359 |
| Map | rs4359 |
| PheGenI | rs4359 |
| Biobank | rs4359 |
| 1000 genomes | rs4359 |
| hgdp | rs4359 |
| ensembl | rs4359 |
| geneview | rs4359 |
| scholar | rs4359 |
| rs4359 | |
| pharmgkb | rs4359 |
| gwascentral | rs4359 |
| openSNP | rs4359 |
| 23andMe | rs4359 |
| SNPshot | rs4359 |
| SNPdbe | rs4359 |
| MSV3d | rs4359 |
| GWAS Ctlg | rs4359 |
| GMAF | 0.4518 |
| Max Magnitude | 0 |
This SNP in the ACE gene, also known as C17888T, is reported to influence how quickly African Americans respond to the anti-hypertensive drug ramipril. rs4359(C;C) and rs4359(T;T) homozygotes are able to reach lower blood pressure levels upon treatment with ramipril sooner than rs4359(C;T) heterozygotes. The odds ratio reported for this study, comparing both homozygotes to heterozygotes, is 1.49 (CI: 1.01-2.13). [PMID 17885551
]
[PMID 24918908] Genomic and Metabolomic Profile Associated to Microalbuminuria
