rs438034

minus

Geno	Mag	Summary
(C;C)	0	normal
(C;T)		poorer survival rate if breast cancer patient
(T;T)		poorer survival rate if breast cancer patient

Reference

GRCh38 38.1/141

Chromosome

1

Position

214657274

Gene

CENPF

is a	snp
is	mentioned by
dbSNP	rs438034
dbSNP (classic)	rs438034
ClinGen	rs438034
ebi	rs438034
HLI	rs438034
Exac	rs438034
Gnomad	rs438034
Varsome	rs438034
LitVar	rs438034
Map	rs438034
PheGenI	rs438034
Biobank	rs438034
1000 genomes	rs438034
hgdp	rs438034
ensembl	rs438034
geneview	rs438034
scholar	rs438034
google	rs438034
pharmgkb	rs438034
gwascentral	rs438034
openSNP	rs438034
23andMe	rs438034
SNPshot	rs438034
SNPdbe	rs438034
MSV3d	rs438034
GWAS Ctlg	rs438034

GMAF

0.3792

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

rs438034 is a SNP in the centromere protein F CENPF gene.

Based on a long-term (up to 15 years) study of 749 Swedish women with breast cancer, carriers of rs438034(T) alleles (as oriented wrt dbSNP) had poorer specific survival rates as compared to rs438034(C;C) individuals. The hazard ratio was 2.65 (CI: 1.19-5.90). However, although rs438034(T) carriers had worse survival odds, they were less likely to have either regional lymph node metastases (odds ratio 0.71, CI: 0.51-1.01) or tumors of stage II-IV (OR 0.73, CI 0.54-0.99). [PMID 19008095]

GWAS snp
PMID	[PMID 21659360 ]
Trait
Title	Association between SNP-genotype and chronic lymphocytic leukemia outcome in a randomized chemotherapy trial.
Risk Allele	T
P-val	0.000005
Odds Ratio	1.8800 [1.44-2.46]