|(A;A)||2.1||1.38x increased risk for prostate cancer|
|?||(A;A) (A;G) (G;G)||28|
rs4430796 is a SNP in the TCF2 gene on chromosome 17q12, associated with increased risk for prostate cancer in several studies.
In a study of over 3,600 Caucasians with prostate cancer, rs4430796 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On its own, the rs4430796(A;A) risk genotype - in dbSNP orientation, not as published - yields an odds ratio for developing prostate cancer of 1.38 (CI: 1.21-1.57, p=1.6x10e-6) and may account for 10.2% of population attributable risk.10.1056/NEJMoa075819
article linking to Prostate cancer and type-2 diabetes
[PMID 18701471] 403 non-Hispanic white families were studied, totaling 1,015 men, to reach the conclusion that the rs4430796(A) allele is associated with increased prostate cancer risk; the odds ratio was 1.40 (CI: 1.09-1.81) under an additive genetic model. Notably, rs4430796(A) was significantly associated with prostate cancer among men diagnosed at an early (<50 years) but not later age (P = 0.006 versus P = 0.118). The increased risk associated with rs4430796 and the closely linked rs7501939 is approximately doubled in individuals hereditarily predisposed to develop early-onset prostate cancer.
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|Odds Ratio||1.18 [1.04-1.32]|
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|Odds Ratio||1.19 [1.10-1.28]|
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|Odds Ratio||1.14 [1.08-1.20]|
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|Odds Ratio||1.1900 [1.12-1.27]|
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|Trait||Type 2 diabetes|
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|Odds Ratio||1.19 [1.13-1.25]|
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|Trait||Type 2 diabetes|
|Title||Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.|
|Odds Ratio||1.13 [1.07-1.09]|
|Trait||Type 2 diabetes|
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|Odds Ratio||1.11 [1.06-1.16]|