rs4458523
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Make rs4458523(G;G) |
| Make rs4458523(G;T) |
| Make rs4458523(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 6288259 |
| Gene | WFS1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4458523 |
| dbSNP (classic) | rs4458523 |
| ClinGen | rs4458523 |
| ebi | rs4458523 |
| HLI | rs4458523 |
| Exac | rs4458523 |
| Gnomad | rs4458523 |
| Varsome | rs4458523 |
| LitVar | rs4458523 |
| Map | rs4458523 |
| PheGenI | rs4458523 |
| Biobank | rs4458523 |
| 1000 genomes | rs4458523 |
| hgdp | rs4458523 |
| ensembl | rs4458523 |
| geneview | rs4458523 |
| scholar | rs4458523 |
| rs4458523 | |
| pharmgkb | rs4458523 |
| gwascentral | rs4458523 |
| openSNP | rs4458523 |
| 23andMe | rs4458523 |
| SNPshot | rs4458523 |
| SNPdbe | rs4458523 |
| MSV3d | rs4458523 |
| GWAS Ctlg | rs4458523 |
| GMAF | 0.2897 |
| Max Magnitude | 0 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
| Rs4458523 | |
|---|---|
| PubMed | [PMID 17603484 ]
|
| Affy Probeset | SNP_A-2217489 |
| Affy Orientation | same |
| On GW 5.0 | 1 |
| Alleles A/B | G/T |
| Ancestral | T |
| Population | Caucasian (UK) |
| Allele | G |
| Case Freq. | |
| Control Freq. | |
| Odds Ratio Het | |
| Odds Ratio Hom | |
| Odds Ratio All | 1.16 |
| Disease | Type II Diabetes (T2D) |
rs4458523 is in linkage disequilibrium with a polymorphism that increases susceptibility to Type II Diabetes 1.16 times for carriers of the G allele [PMID 17603484]
| GWAS snp | |
|---|---|
| PMID | [PMID 24509480]
|
| Trait | Type 2 diabetes |
| Title | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. |
| Risk Allele | G |
| P-val | 2E-9 |
| Odds Ratio | 1.09 [1.06-1.13] |
