rs4496877

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(G;G)	0
(G;T)	1.1	For type-1 diabetics, 1.3x increased nephropathy risk
(T;T)	1.2	For type-1 diabetics, 1.6x increased nephropathy risk

Reference

GRCh38 38.1/141

Chromosome

7

Position

150983418

Gene

NOS3

is a	snp
is	mentioned by
dbSNP	rs4496877
dbSNP (classic)	rs4496877
ClinGen	rs4496877
ebi	rs4496877
HLI	rs4496877
Exac	rs4496877
Gnomad	rs4496877
Varsome	rs4496877
LitVar	rs4496877
Map	rs4496877
PheGenI	rs4496877
Biobank	rs4496877
1000 genomes	rs4496877
hgdp	rs4496877
ensembl	rs4496877
geneview	rs4496877
scholar	rs4496877
google	rs4496877
pharmgkb	rs4496877
gwascentral	rs4496877
openSNP	rs4496877
23andMe	rs4496877
SNPshot	rs4496877
SNPdbe	rs4496877
MSV3d	rs4496877
GWAS Ctlg	rs4496877

GMAF

0.2199

Max Magnitude

1.2

rs4496877 is a SNP near the NOS3 gene.

Several Type-1 diabetes patients pools, totaling over 2,000 patients, plus a meta-analysis were involved in a study concluding that in such patients, the rs4496877 was associated with higher risk for nephropathy. The odds ratio associated with rs4496877(T) was 1.26 (p = 0.002, CI: 1.08-1.47).[PMID 20962522]

A proxy for this SNP (pairwise linkage of 0.96) is rs1800783.

?	(G;G) (G;T) (T;T)	28

[PMID 19505917] Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.