rs450046
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common in clinvar |
| (T;T) | 0 |
| Make rs450046(C;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 22 |
| Position | 18913491 |
| Gene | PRODH |
| is a | snp |
| is | mentioned by |
| dbSNP | rs450046 |
| dbSNP (classic) | rs450046 |
| ClinGen | rs450046 |
| ebi | rs450046 |
| HLI | rs450046 |
| Exac | rs450046 |
| Gnomad | rs450046 |
| Varsome | rs450046 |
| LitVar | rs450046 |
| Map | rs450046 |
| PheGenI | rs450046 |
| Biobank | rs450046 |
| 1000 genomes | rs450046 |
| hgdp | rs450046 |
| ensembl | rs450046 |
| geneview | rs450046 |
| scholar | rs450046 |
| rs450046 | |
| pharmgkb | rs450046 |
| gwascentral | rs450046 |
| openSNP | rs450046 |
| 23andMe | rs450046 |
| SNPshot | rs450046 |
| SNPdbe | rs450046 |
| MSV3d | rs450046 |
| GWAS Ctlg | rs450046 |
| GMAF | 0.08678 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
also referred to as 1766A/G
plos rs450046 was most strongly positively associated with schizophrenia in families.
[PMID 19232576] rs372055(C), rs450046(G), rs385440(A) haplotype carriers (n = 32) exhibited attenuated PPI + verbal memory (p < .001) as well as higher anxiety (p < .004) and schizotypy (p < .008) compared to noncarriers (n = 185)
| ClinVar | |
|---|---|
| Risk | Rs450046(T;T) |
| Alt | Rs450046(T;T) |
| Reference | Rs450046(C;C) |
| Significance | Other |
| Disease | Proline dehydrogenase deficiency Schizophrenia 4 not provided |
| Variation | info |
| Gene | PRODH |
| CLNDBN | Proline dehydrogenase deficiency Schizophrenia 4 not provided |
| Reversed | 0 |
| HGVS | NC_000022.10:g.18901004C\x3d |
| CLNSRC | OMIM Allelic Variant |
| CLNACC | RCV000004222.5, RCV000004223.5, RCV000115065.1, |
[PMID 17708757
] Genome bioinformatic analysis of nonsynonymous SNPs.
[PMID 18408230] Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?
[PMID 18989458] Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function.
[PMID 19693005] Executive function, neural circuitry, and genetic mechanisms in schizophrenia.
