rs4516035
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | if less milk in teenage females, less bone? | |
| (C;T) | if less milk in teenage females, less bone? | |
| (T;T) | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 12 |
| Position | 47906043 |
| Gene | VDR |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4516035 |
| dbSNP (classic) | rs4516035 |
| ClinGen | rs4516035 |
| ebi | rs4516035 |
| HLI | rs4516035 |
| Exac | rs4516035 |
| Gnomad | rs4516035 |
| Varsome | rs4516035 |
| LitVar | rs4516035 |
| Map | rs4516035 |
| PheGenI | rs4516035 |
| Biobank | rs4516035 |
| 1000 genomes | rs4516035 |
| hgdp | rs4516035 |
| ensembl | rs4516035 |
| geneview | rs4516035 |
| scholar | rs4516035 |
| rs4516035 | |
| pharmgkb | rs4516035 |
| gwascentral | rs4516035 |
| openSNP | rs4516035 |
| 23andMe | rs4516035 |
| SNPshot | rs4516035 |
| SNPdbe | rs4516035 |
| MSV3d | rs4516035 |
| GWAS Ctlg | rs4516035 |
| GMAF | 0.2149 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
A very small study of 117 healthy European peri- and postmenarcheal girls (14.9 +/- 1.6 years) were followed for 4 years along with their calcium intake. Girls with rs4516035(C;T) and (C;C) genotypes had 13% lower spine mineral content if their milk intakes were below 260 mL/day, compared to either genotype-matched girls with higher milk intakes or to girls with the (T;T) genotype. If this is real, it suggests that rs4516035(C;T) and (C;C) female teens need more milk than rs4516035(T;T) girls to have optimal bone density.
[PMID 19105801
] rs4516035 and the more aggressive tumour location in head-neck and trunk (OR=1.54, p=0.020)
[PMID 18587672] Vitamin D receptor variants and breast cancer risk in the Polish population
[PMID 20046590] The unfavorable effect of the A allele of the vitamin D receptor promoter polymorphism A-1012G has different mechanisms related to susceptibility and outcome of malignant melanoma
[PMID 20394945] Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment
[PMID 21365644] Vitamin D receptor polymorphisms in patients with cutaneous melanoma
[PMID 22544453] Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma
[PMID 17130574] Protection from type 1 diabetes by vitamin D receptor haplotypes.
[PMID 18205531] Vitamin D receptor gene haplotypes and susceptibility to HIV-1 infection in injection drug users.
[PMID 19309297] Higher milk requirements for bone mineral accrual in adolescent girls bearing specific caucasian genotypes in the VDR promoter.
[PMID 19450131] Application of pharmacogenomics to vaccines.
[PMID 19615888] Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data.
[PMID 19679055] Vitamin D receptor variants and the malignant melanoma risk: a population-based study.
[PMID 19682379] TagSNP transferability and relative loss of variability prediction from HapMap to an admixed population.
[PMID 20015871] Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia.
[PMID 20398755] Growth, calcium status and vitamin D receptor (VDR) promoter genotype in European children with normal or low calcium intake.
[PMID 20716226] Clinical and genetic predictors of response to narrowband ultraviolet B for the treatment of chronic plaque psoriasis.
[PMID 26303648] Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk
[PMID 30150596] Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women.
