rs4648317
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal |
| (C;T) | prone to higher nicotine dependence? | |
| (T;T) | 1.2 | prone to higher nicotine dependence, more impulsive/sensation seeking |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 113460810 |
| Gene | DRD2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4648317 |
| dbSNP (classic) | rs4648317 |
| ClinGen | rs4648317 |
| ebi | rs4648317 |
| HLI | rs4648317 |
| Exac | rs4648317 |
| Gnomad | rs4648317 |
| Varsome | rs4648317 |
| LitVar | rs4648317 |
| Map | rs4648317 |
| PheGenI | rs4648317 |
| Biobank | rs4648317 |
| 1000 genomes | rs4648317 |
| hgdp | rs4648317 |
| ensembl | rs4648317 |
| geneview | rs4648317 |
| scholar | rs4648317 |
| rs4648317 | |
| pharmgkb | rs4648317 |
| gwascentral | rs4648317 |
| openSNP | rs4648317 |
| 23andMe | rs4648317 |
| SNPshot | rs4648317 |
| SNPdbe | rs4648317 |
| MSV3d | rs4648317 |
| GWAS Ctlg | rs4648317 |
| GMAF | 0.2365 |
| Max Magnitude | 1.2 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs4648317, a SNP in the dopamine D2 receptor DRD2 gene, has been linked to higher rates of smoking and higher nicotine dependence scores, based on a study of ~220 adolescents. The risk allele rs4648317(T).[PMID 18434921]
[PMID 19373123] Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution
[PMID 19512960] Genetic diagnostics of functional variants of the human dopamine D2 receptor gene
[PMID 19968402
] Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants
[PMID 18077373] Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.
[PMID 22244514] Sensorimotor gating and D2 receptor signalling: evidence from a molecular genetic approach.
[PMID 31867628] Genetic and epigenetic analysis revealing variants in the NCAM1-TTC12-ANKK1-DRD2 cluster associated significantly with nicotine dependence in Chinese Han smokers.
[PMID 31933869] Functional tag SNPs inside the DRD2 gene as a genetic risk factor for major depressive disorder in the Chinese Han population.
[PMID 33043160] Association of DRD2 gene polymorphisms with schizophrenia in the young Bangladeshi population: A pilot study.
