rs4696480
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;T) | 1 | preterm birth |
| Make rs4696480(A;A) |
| Make rs4696480(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 153685974 |
| Gene | TLR2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4696480 |
| dbSNP (classic) | rs4696480 |
| ClinGen | rs4696480 |
| ebi | rs4696480 |
| HLI | rs4696480 |
| Exac | rs4696480 |
| Gnomad | rs4696480 |
| Varsome | rs4696480 |
| LitVar | rs4696480 |
| Map | rs4696480 |
| PheGenI | rs4696480 |
| Biobank | rs4696480 |
| 1000 genomes | rs4696480 |
| hgdp | rs4696480 |
| ensembl | rs4696480 |
| geneview | rs4696480 |
| scholar | rs4696480 |
| rs4696480 | |
| pharmgkb | rs4696480 |
| gwascentral | rs4696480 |
| openSNP | rs4696480 |
| 23andMe | rs4696480 |
| SNPshot | rs4696480 |
| SNPdbe | rs4696480 |
| MSV3d | rs4696480 |
| GWAS Ctlg | rs4696480 |
| GMAF | 0.4601 |
| Max Magnitude | 1 |
| ? | (A;A) (A;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs4696480 (T-16934A and Arg753Gln) and rs5743708) (Thr399Ile) earlier birth for infants carrying two (-16934TA/AA and 753ArgGln/GlnGln)
[PMID 20685742] Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma
[PMID 21371045] TLR2 polymorphisms influence neonatal regulatory T cells depending on maternal atopy
[PMID 17565608
] Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis.
[PMID 18396467] Genetic variation and haplotype structures of innate immunity genes in eastern India.
[PMID 19029192] A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma.
[PMID 19134200] No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis.
[PMID 19543401] Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
[PMID 20113509] Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts.
[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.
[PMID 20599261] Gene-gene interaction in regulatory T-cell function in atopy and asthma development in childhood.
[PMID 21356257] Toll-like receptor (TLR) 2 promoter and intron 2 polymorphisms are associated with increased risk for spontaneous bacterial peritonitis in liver cirrhosis.
[PMID 21437199] Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population.
[PMID 21500195] The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C.
[PMID 21872627] Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.
[PMID 23161283] SNPs in toll-like receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis?
[PMID 24971461] Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort
[PMID 25790282] Combined Effect of TLR2 Gene Polymorphism and Early Life Stress on the Age at Onset of Bipolar Disorders
[PMID 24776844] Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease
[PMID 26846412] Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study.
[PMID 27155792] TLR2 and TLR4 polymorphisms in Southern Chinese Psoriasis Vulgaris patients.
[PMID 27207565] Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene-environment interaction study.
[PMID 28490891] No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations.
[PMID 28518213] Relationship between toll-like receptor 2 R753Q and T16934A polymorphisms and Staphylococcus aureus nasal carriage.
[PMID 28624699] Toll-like receptor 2 rs4696480 polymorphism and risk of oral cancer and oral potentially malignant disorder.
[PMID 30532554] Potential role of Toll-like receptor 2 expression and polymorphisms in colon cancer susceptibility in the Saudi Arabian population.
[PMID 31125591] The polymorphism rs4696480 in the TLR2 gene is associated with psoriasis patients in the Turkish population.
[PMID 33013863] Polymorphisms in Inflammatory Genes Modulate Clinical Complications in Patients With Sickle Cell Disease.
