||0.47x decreased risk for bipolar disorder
||0.69x decreased risk for bipolar disorder
rs4713902, a SNP in the FKBP5 gene, is associated with increased risk for bipolar disorder in a study of 500+ Caucasian patients.
The most common allele, rs4713902(T), was associated with highest risk. Giving that allele a relative odds ratio of 1.0, the odds for the (C;T) and (C;C) genotypes were 0.69x (CI:0.55-0.88, p=0.001) and 0.47 (CI: 0.30-0.74, p=0.001).[PMID 18180755]
[PMID 20090668] Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide
[PMID 15637659] Linkage disequilibrium patterns and tagSNP transferability among European populations.
[PMID 23274505] Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults