rs4728142

Orientation

plus

Stabilized

plus

Make rs4728142(A;A)

Make rs4728142(A;G)

Make rs4728142(G;G)

Reference

GRCh38 38.1/141

Chromosome

7

Position

128933913

is a	snp
is	mentioned by
dbSNP	rs4728142
dbSNP (classic)	rs4728142
ClinGen	rs4728142
ebi	rs4728142
HLI	rs4728142
Exac	rs4728142
Gnomad	rs4728142
Varsome	rs4728142
LitVar	rs4728142
Map	rs4728142
PheGenI	rs4728142
Biobank	rs4728142
1000 genomes	rs4728142
hgdp	rs4728142
ensembl	rs4728142
geneview	rs4728142
scholar	rs4728142
google	rs4728142
pharmgkb	rs4728142
gwascentral	rs4728142
openSNP	rs4728142
23andMe	rs4728142
SNPshot	rs4728142
SNPdbe	rs4728142
MSV3d	rs4728142
GWAS Ctlg	rs4728142

GMAF

0.2961

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

[PMID 18285424] rs4728142, rs3807306 and a 5 bp insertion-deletion linked multiple sclerosis in three populations

GWAS snp
PMID	[PMID 19838193]
Trait	Systemic lupus erythematosus
Title	Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
Risk Allele	A
P-val	8E-19
Odds Ratio	1.43 [1.32-1.54]

OMIM	612251
Desc
Variant
Related	also

GWAS snp
PMID	[PMID 21297633]
Trait
Title	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Risk Allele	A
P-val	2E-8
Odds Ratio	1.0700 [1.03-1.11]

[PMID 21471993] Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferon? therapy in multiple sclerosis

[PMID 22440820] IRF5 polymorphism predicts prognosis in patients with systemic sclerosis

[PMID 17412832] Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.

[PMID 19772658] Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation.

[PMID 20169177] Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.

[PMID 20383147] Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.

[PMID 20479942] Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.

[PMID 20691091] Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data.

[PMID 20861862] Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection.

[PMID 22257839] A two-marker haplotype in the IRF5 gene is associated with inflammatory bowel disease in a North American cohort.

[PMID 23372721] The Systemic Lupus Erythematosus IRF5 Risk Haplotype Is Associated with Systemic Sclerosis

GWAS snp
PMID	[PMID 23128233]
Trait	Ulcerative colitis
Title	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Risk Allele	A
P-val	4E-14
Odds Ratio	1.10 [1.066-1.143]

[PMID 23971939] IRF5, but not TLR4, DEFEB1, or VDR, is associated with the risk of ulcerative colitis in a Han Chinese population

[PMID 23023776] European genetic ancestry is associated with a decreased risk of lupus nephritis.

[PMID 25205108] The IRF5-TNPO3 association with systemic lupus erythematosus (SLE) has two components that other autoimmune disorders variably share

GWAS snp
PMID	[PMID 24871463]
Trait	Systemic lupus erythematosus
Title	GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
Risk Allele	A
P-val	7E-10
Odds Ratio	1.45 [1.368-1.55]

[PMID 25337792] Genetic association study of TNFAIP3, IFIH1, IRF5 polymorphisms with polymyositis/dermatomyositis in Chinese Han population

[PMID 26398853] Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans