rs4796793
| Orientation | plus |
| Stabilized | plus |
| Make rs4796793(C;C) |
| Make rs4796793(C;G) |
| Make rs4796793(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 17 |
| Position | 42390192 |
| Gene | STAT3 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4796793 |
| dbSNP (classic) | rs4796793 |
| ClinGen | rs4796793 |
| ebi | rs4796793 |
| HLI | rs4796793 |
| Exac | rs4796793 |
| Gnomad | rs4796793 |
| Varsome | rs4796793 |
| LitVar | rs4796793 |
| Map | rs4796793 |
| PheGenI | rs4796793 |
| Biobank | rs4796793 |
| 1000 genomes | rs4796793 |
| hgdp | rs4796793 |
| ensembl | rs4796793 |
| geneview | rs4796793 |
| scholar | rs4796793 |
| rs4796793 | |
| pharmgkb | rs4796793 |
| gwascentral | rs4796793 |
| openSNP | rs4796793 |
| 23andMe | rs4796793 |
| SNPshot | rs4796793 |
| SNPdbe | rs4796793 |
| MSV3d | rs4796793 |
| GWAS Ctlg | rs4796793 |
| GMAF | 0.3411 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs4796793, a SNP in the 5' region of the signal transducer and activator 3 STAT3 gene, has been linked in a study of 75 Japanese patients to (successful) response to interferon-alpha immunotherapy for metastatic kidney cancer. [PMID 17602083]
From this paper [PMID 17602083]:
"... rs4796793 was the most significant predictor of IFN-alpha response (odds ratio [OR] = 2.73; 95% CI, 1.38 to 5.78). The highest OR was shown in the (C;C) genotype ... compared to the (G;G) + (G;C) genotypes (OR = 8.38, 95% CI, 1.63 to 42.96)."
[PMID 19604093
] Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.
[PMID 21948258] Association between polymorphisms in the signal transducer and activator of transcription and dilated cardiomyopathy in the Chinese Han population.
[PMID 24781989] Association between STAT3 gene polymorphisms and ulcerative colitis susceptibility: a case-control study in the Chinese Han population
[PMID 25973100] STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical outcomes
