| Rs4821544
|
| PubMed
|
[PMID 17435756 ]
|
| Affy Probeset
|
SNP_A-2222922
|
| Affy Orientation
|
same
|
| On GW 5.0
|
1
|
| Alleles A/B
|
C/T
|
| Ancestral
|
C
|
| Population
|
EU
|
| Allele
|
C
|
| Case Freq.
|
0.4
|
| Control Freq.
|
0.33
|
| Odds Ratio Het
|
|
| Odds Ratio Hom
|
|
| Odds Ratio All
|
1.19
|
| Disease
|
Crohn's disease (CD)
|
A study of 507 CD patients, 475 UC patients and 576 controls from New Zealand Caucasians found that rs4821544, a SNP in the NCF4 gene, was associated specifically with ileal Crohn's disease but not with other forms of inflammatory bowel disease. The reported odds ratio was 1.425, CI: 1.092-1.859, p=0.009.[PMID 18580884]
rs4821544 increases susceptibility to Crohn's disease 1.19 times for carriers of the C allele [PMID 17435756]
[PMID 19262523] rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population
[PMID 22115380] Prediction of disease complication occurrence in Crohn's disease using phenotype and genotype parameters at diagnosis
| GWAS snp
|
| PMID
|
[PMID 22197932]
|
| Trait
|
|
| Title
|
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
|
| Risk Allele
|
C
|
| P-val
|
0.000006
|
| Odds Ratio
|
1.0900 None
|
[PMID 17068223] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
[PMID 29228965] Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease.
]
