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rs4950

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(T;T) 1 Most common genotype in several populations; yet also higher leadership occupancy?
Make rs4950(C;C)
Make rs4950(C;T)
ReferenceGRCh38 38.1/142
Chromosome8
Position42697490
GeneCHRNB3, LOC105379396
is asnp
is mentioned by
dbSNPrs4950
dbSNP (classic)rs4950
ClinGenrs4950
ebirs4950
HLIrs4950
Exacrs4950
Gnomadrs4950
Varsomers4950
LitVarrs4950
Maprs4950
PheGenIrs4950
Biobankrs4950
1000 genomesrs4950
hgdprs4950
ensemblrs4950
geneviewrs4950
scholarrs4950
googlers4950
pharmgkbrs4950
gwascentralrs4950
openSNPrs4950
23andMers4950
23andMe allrs4950
SNPshotrs4950
SNPdbers4950
MSV3drs4950
GWAS Ctlgrs4950
GMAF0.3618
Max Magnitude1
? (C;C) (C;T) (T;T) 28


One paper published in 2013 (and not replicated since then to our knowledge), titled "Born to Lead? A Twin Design and Genetic Association Study of Leadership Role Occupancy", performed a GWAS study that concluded that leadership role occupancy is associated with rs4950, a SNP in the neuronal acetylcholine receptor gene (CHRNB3). Individuals with the rs4950(T;T) genotype (as oriented in dbSNP and SNPedia) are statistically more likely (odds ratio ~1.5) to occupy leadership positions as compared to rs4950(C;T) or (C;C) individuals.[PMID 23459689OA-icon.png]

Popular news about this finding includes: http://www.sciencedaily.com/releases/2013/01/130115111553.htm and https://www.23andme.com/you/community/thread/16689/


[PMID 18055561] The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco.


[PMID 18571741OA-icon.png] Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.


[PMID 18704094OA-icon.png] Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.


[PMID 19259974OA-icon.png] Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.


[PMID 19492010OA-icon.png] The genetic components of alcohol and nicotine co-addiction: from genes to behavior.


[PMID 19500157OA-icon.png] SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample.