rs4968451

plus

Geno	Mag	Summary
(A;A)	0	Normal risk for meningioma
(A;C)	2	1.61x increased risk for meningioma
(C;C)	2.1	2.33x increased risk for meningioma

Reference

GRCh38 38.1/141

Chromosome

17

Position

61849946

Gene

BRIP1

is a	snp
is	mentioned by
dbSNP	rs4968451
dbSNP (classic)	rs4968451
ClinGen	rs4968451
ebi	rs4968451
HLI	rs4968451
Exac	rs4968451
Gnomad	rs4968451
Varsome	rs4968451
LitVar	rs4968451
Map	rs4968451
PheGenI	rs4968451
Biobank	rs4968451
1000 genomes	rs4968451
hgdp	rs4968451
ensembl	rs4968451
geneview	rs4968451
scholar	rs4968451
google	rs4968451
pharmgkb	rs4968451
gwascentral	rs4968451
openSNP	rs4968451
23andMe	rs4968451
SNPshot	rs4968451
SNPdbe	rs4968451
MSV3d	rs4968451
GWAS Ctlg	rs4968451

GMAF

0.2516

Max Magnitude

2.1

?

(A;A) (A;C) (C;C)

28

rs4968451, which is in a breast cancer susceptibility gene, was associated with increased risk of meningioma, a common form of brain tumor, in a combination of five studies totaling 631 European case patients as well 637 European control subjects.

"Meningioma risks associated with hetero- and homozygosity for the minor allele of were 1.61 (95% CI = 1.26 to 2.06) and 2.33 (95% CI = 1.25 to 4.34), respectively, and were thus compatible with a multiplicative model of action." The risk allele and minor allele is rs4968451(C). Around 30% of Europeans carry one of risk genotypes, i.e. rs4968451(A;C) or (C;C); and perhaps 16% of meningiomas might be associated with this SNP.[PMID 18270339]

[PMID 18505952 ] Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.

[PMID 19276285 ] Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.

[PMID 29581016] CASP8, XRCC1, WRN, NF2 and BRIP1 polymorphisms analysis reveals their genetic susceptibility for meningioma risk and the association with tumor-related phenotype in Chinese population.