rs5082
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2.5 | saturated fat contributes to obesity, but 0.57 % lower risk for coronary artery disease |
| (C;T) | 0 | normal risk |
| (T;T) | 0 | normal risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 161223893 |
| Gene | APOA2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs5082 |
| dbSNP (classic) | rs5082 |
| ClinGen | rs5082 |
| ebi | rs5082 |
| HLI | rs5082 |
| Exac | rs5082 |
| Gnomad | rs5082 |
| Varsome | rs5082 |
| LitVar | rs5082 |
| Map | rs5082 |
| PheGenI | rs5082 |
| Biobank | rs5082 |
| 1000 genomes | rs5082 |
| hgdp | rs5082 |
| ensembl | rs5082 |
| geneview | rs5082 |
| scholar | rs5082 |
| rs5082 | |
| pharmgkb | rs5082 |
| gwascentral | rs5082 |
| openSNP | rs5082 |
| 23andMe | rs5082 |
| SNPshot | rs5082 |
| SNPdbe | rs5082 |
| MSV3d | rs5082 |
| GWAS Ctlg | rs5082 |
| GMAF | 0.2521 |
| Max Magnitude | 2.5 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs5082 is a SNP in the apolipoprotein APOA2 gene, and may influence obesity and heart disease risk.
Individuals homozygous for the -265T>C polymorphism in rs5082, i.e. individuals with the rs5082(C;C) genotype of the Apolipoprotein A-II gene (APOA2) promoter, are associated with increased Body Mass Index and food intake in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study of ~1000 individuals. The odds ratio for obesity in (C;C) individuals compared to rs5082(T) allele carriers was 1.70 (CI: 1.02-2.80, p=0.039). Total energy, total fat, and total protein intake were all significantly higher in (C;C) individuals.[PMID 17446329]
In a separate study, a case-control analysis of 484 Australian male coronary artery disease patients and 498 male controls concluded that rs5082(C;C) individuals were at significantly lower risk for that form of heart disease than rs5082(T) allele carriers (odds ratio 0.57, CI: 0.39-0.84, p=0.004).[PMID 18179799]
A meta-analysis of several APOA2 SNPs (including this one) found no association between any APOA2 SNPs studied and type-2 diabetes.[PMID 19216768
]
[PMID 17709437] An apolipoprotein A-II polymorphism (-265T/C, rs5082) regulates postprandial response to a saturated fat overload in healthy men.
[PMID 18304332] No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins.
[PMID 24108135] Apolipoprotein A2 Polymorphism Interacts with Intakes of Dairy Foods to Influence Body Weight in Two U.S. Populations
[PMID 26210798] APOA II genotypes frequency and their interaction with saturated fatty acids consumption on lipid profile of patients with type 2 diabetes
[PMID 26590203] Identification of Sequence Variation in the Apolipoprotein A2 Gene and Their Relationship with Serum High-Density Lipoprotein Cholesterol Levels
