rs603965

plus

Geno	Mag	Summary
(A;A)	0	normal
(A;G)		?
(G;G)		increased breast cancer risk

Reference

GRCh38 38.1/141

Chromosome

11

Position

69648142

Gene	CCND1, LOC100996515

is a	snp
is	mentioned by
dbSNP	rs603965
dbSNP (classic)	rs603965
ClinGen	rs603965
ebi	rs603965
HLI	rs603965
Exac	rs603965
Gnomad	rs603965
Varsome	rs603965
LitVar	rs603965
Map	rs603965
PheGenI	rs603965
Biobank	rs603965
1000 genomes	rs603965
hgdp	rs603965
ensembl	rs603965
geneview	rs603965
scholar	rs603965
google	rs603965
pharmgkb	rs603965
gwascentral	rs603965
openSNP	rs603965
23andMe	rs603965
SNPshot	rs603965
SNPdbe	rs603965
MSV3d	rs603965
GWAS Ctlg	rs603965

Status

Merged into rs9344

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

rs603965 is a SNP in the cyclin D1 CCND1 gene. It is also known as Pro241Pro. The associated genotypes are characterized in terms of their enzymatic activity as High for (A;A), Medium (A;G), and Low (G;G).

In a study of 2 populations of breast cancer patients (2,000+ patients), increased risk was associated with rs603965(A;A) genotypes in both the Ontario [odds ratio 2.22, CI: 1.49-3.28] and Finland [OR 1.73, CI: 1.08-2.78] populations.[PMID 18194538 ]

GWAS snp
PMID	[PMID 23502783 ]
Trait	Multiple myeloma (IgH translocation)
Title	The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
Risk Allele	G
P-val	2E-11
Odds Ratio	1.95 [1.61-2.38]

[PMID 24264314] Association between CCND1 and XPC polymorphisms and bladder cancer risk: a meta-analysis based on 15 case-control studies

[PMID 27156331] SNP rs1059234 in CDKN1A Gene Correlates with Prognosis in Resected Gastric Adenocarcinoma.

[PMID 28380465 ] Impact of interaction between the G870A and EFEMP1 gene polymorphism on glioma risk in Chinese Han population.