rs6190
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | common in complete genomics |
| Make rs6190(A;A) |
| Make rs6190(A;G) |
| Reference | GRCh38 38.1/142 |
| Chromosome | 5 |
| Position | 143400772 |
| Gene | NR3C1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6190 |
| dbSNP (classic) | rs6190 |
| ClinGen | rs6190 |
| ebi | rs6190 |
| HLI | rs6190 |
| Exac | rs6190 |
| Gnomad | rs6190 |
| Varsome | rs6190 |
| LitVar | rs6190 |
| Map | rs6190 |
| PheGenI | rs6190 |
| Biobank | rs6190 |
| 1000 genomes | rs6190 |
| hgdp | rs6190 |
| ensembl | rs6190 |
| geneview | rs6190 |
| scholar | rs6190 |
| rs6190 | |
| pharmgkb | rs6190 |
| gwascentral | rs6190 |
| openSNP | rs6190 |
| 23andMe | rs6190 |
| SNPshot | rs6190 |
| SNPdbe | rs6190 |
| MSV3d | rs6190 |
| GWAS Ctlg | rs6190 |
| GMAF | 0.01331 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
The association reported in [PMID 20472303] was not replicated in [PMID 20680430
].
[PMID 20472303] Associations between common arginine vasopressin 1b receptor and glucocorticoid receptor gene variants and HPA axis responses to psychosocial stress in a child psychiatric population
[PMID 21633323] Variation in the glucocorticoid receptor gene (NR3C1) may be associated with corticosteroid dependency and resistance in children with Crohn's disease
[PMID 20712049] Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients.
[PMID 21448414] Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.
[PMID 21803757] Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome.
[PMID 22781842] Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior
[PMID 25724472] Polymorphisms in the glucocorticoid receptor gene and in the glucocorticoid-induced transcript 1 gene are associated with disease activity and response to glucocorticoid bridging therapy in rheumatoid arthritis
| ClinVar | |
|---|---|
| Risk | rs6190(A;A) |
| Alt | rs6190(A;A) |
| Reference | Rs6190(G;G) |
| Significance | Probable-non-pathogenic |
| Disease | Glucocorticoid resistance |
| Variation | info |
| Gene | NR3C1 |
| CLNDBN | Glucocorticoid resistance |
| Reversed | 1 |
| HGVS | NC_000005.9:g.142780337C>T |
| CLNSRC | OMIM Allelic Variant |
| CLNACC | RCV000317840.1, |
[PMID 33562675] The Glucocorticoid Receptor Gene (NR3C1) 9β SNP Is Associated with Posttraumatic Stress Disorder.
