rs6323
| Monoamine oxidase A activity |
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 2.1 | Increased monoamine oxidase A activity |
| (T;T) | 3 | reduced MAOA activity |
| Make rs6323(G;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | X |
| Position | 43731789 |
| Gene | MAOA |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6323 |
| dbSNP (classic) | rs6323 |
| ClinGen | rs6323 |
| ebi | rs6323 |
| HLI | rs6323 |
| Exac | rs6323 |
| Gnomad | rs6323 |
| Varsome | rs6323 |
| LitVar | rs6323 |
| Map | rs6323 |
| PheGenI | rs6323 |
| Biobank | rs6323 |
| 1000 genomes | rs6323 |
| hgdp | rs6323 |
| ensembl | rs6323 |
| geneview | rs6323 |
| scholar | rs6323 |
| rs6323 | |
| pharmgkb | rs6323 |
| gwascentral | rs6323 |
| openSNP | rs6323 |
| 23andMe | rs6323 |
| SNPshot | rs6323 |
| SNPdbe | rs6323 |
| MSV3d | rs6323 |
| GWAS Ctlg | rs6323 |
| GMAF | 0.3319 |
| Max Magnitude | 3 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs6323 (R297R / Arg297Arg) is a SNP in the MAOA (monoamine oxidase A) gene. Monoamine oxidase A degrades serotonin, dopamine, epinephrine, and norepinephrine. The G allele encodes for the higher activity form of the enzyme.
[PMID 20691428] A cis-Phase Interaction Study of Genetic Variants Within the MAOA Gene in Major Depressive Disorder
[PMID 19593178] Subjects with major depressive disorder with the highest activity form of the enzyme (G or G/G) had a significantly lower magnitude of placebo response.
[PMID 21978760
] Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese
[PMID 16174289] MAOA haplotypes associated with thrombocyte-MAO activity.
[PMID 17417058] Monoamine oxidase a gene is associated with borderline personality disorder.
[PMID 18180394] Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans.
[PMID 18501009] Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese.
[PMID 19693267] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21216270] Role of gene-gene/gene-environment interaction in the etiology of eastern Indian ADHD probands.
[PMID 21680027] Influence and interaction of genetic polymorphisms in catecholamine neurotransmitter systems and early life stress on antidepressant drug response.
[PMID 22162429] Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population.
[PMID 23111930] MAOA and MAOB polymorphisms and anger-related traits in suicidal participants and controls
| ClinVar | |
|---|---|
| Risk | Rs6323(T;T) |
| Alt | Rs6323(T;T) |
| Reference | Rs6323(G;G) |
| Significance | Other |
| Disease | not specified |
| Variation | info |
| Gene | MAOA |
| CLNDBN | not specified |
| Reversed | 0 |
| HGVS | NC_000023.10:g.43591036G>T |
| CLNSRC | ClinVar Emory University University of Chicago |
| CLNACC | RCV000078415.8, |
[PMID 30692067] [Postpartum depression: association with genetic polymorphisms of noradrenaline metabolic enzymes and the risk factors].
