MAOA
| is a | gene |
| is | mentioned by |
| Full name | monoamine oxidase A |
| Related | MAOB |
| EntrezGene | 4128 |
| PheGenI | 4128 |
| VariationViewer | 4128 |
| ClinVar | MAOA |
| GeneCards | MAOA |
| dbSNP | 4128 |
| Diseases | MAOA |
| SADR | 4128 |
| HugeNav | 4128 |
| wikipedia | oxidase A Monoamine oxidase A |
| MAOA | |
| gopubmed | MAOA |
| EVS | MAOA |
| HEFalMp | MAOA |
| MyGene2 | MAOA |
| 23andMe | MAOA |
| UniProt | P21397 |
| Ensembl | ENSG00000189221 |
| OMIM | 309850 |
| # SNPs | 20 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1137070 | 0 | 43,744,144 | |
| rs1465107 | 0 | 43,678,769 | |
| rs2072743 | 0 | 43,740,274 | |
| rs2235186 | 0 | 43,736,181 | |
| rs2283725 | 0 | 43,700,729 | |
| rs3027400 | 0 | 43,733,516 | |
| rs3027407 | 0 | 43,745,594 | |
| rs3027409 | 0 | 43,747,786 | |
| rs3788862 | 0 | 43,658,116 | |
| rs587777457 | 0 | 43,731,695 | |
| rs5906883 | 0 | 43,667,695 | |
| rs5906957 | 0 | 43,688,062 | |
| rs5953210 | 0 | 43,654,798 | |
| rs6323 | 3 | 43,731,789 | Monoamine oxidase A activity |
| rs6609257 | 0 | 43,753,461 | |
| rs72554632 | 5 | 43,731,784 | |
| rs796065311 | 0 | 43,731,344 | |
| rs796065312 | 0 | 43,683,572 | |
| rs909525 | 2 | 43,693,955 | Best proxy for Warrior Gene repeats. |
| rs979606 | 0 | 43,741,895 |
The MAOA monoamine-oxidase A gene, encodes an enzyme partially responsible for the metabolism of several neurotransmitters such as dopamine and serotonin. The monoamine oxidase family of enzymes, which metabolize monoamines (neurotransmitters and neuromodulators consisting of a single amine), includes MAOA and MAOB.
Although not a SNP per se, the variation that has been most studied consists of a 30 base-pair variable number tandem repeat (VNTR) located in the promoter region of the gene. Alleles with 3.5 and 4 repeats are 2-10 times more productive than the allele with 3 repeats. Several studies have shown an association between the 3-repeat allele and neuropsychiatric conditions such as alcoholism, antisocial personality, impulsivity, and poor reaction to stress, leading some popular media to label this allele the "warrior gene".
blog affects aggression after provocation pnas
Brunner syndrome: a recessive X-linked disorder characterized by impulsive aggressiveness and mild mental retardation resulting from MAOA deficiency OMIM; dbSNP reports a probably pathogenic allele detected by SNP rs72554632 C/T CAT->TAG QLN->STOP(AMBER), the same SNP associated with Brunner syndrome.
