rs6330
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | more anxious females, less anxious males |
| (C;T) | normal | |
| (T;T) | more anxious males, less anxious females |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 115286692 |
| Gene | NGF |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6330 |
| dbSNP (classic) | rs6330 |
| ClinGen | rs6330 |
| ebi | rs6330 |
| HLI | rs6330 |
| Exac | rs6330 |
| Gnomad | rs6330 |
| Varsome | rs6330 |
| LitVar | rs6330 |
| Map | rs6330 |
| PheGenI | rs6330 |
| Biobank | rs6330 |
| 1000 genomes | rs6330 |
| hgdp | rs6330 |
| ensembl | rs6330 |
| geneview | rs6330 |
| scholar | rs6330 |
| rs6330 | |
| pharmgkb | rs6330 |
| gwascentral | rs6330 |
| openSNP | rs6330 |
| 23andMe | rs6330 |
| SNPshot | rs6330 |
| SNPdbe | rs6330 |
| MSV3d | rs6330 |
| GWAS Ctlg | rs6330 |
| GMAF | 0.3058 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs6330 is a SNP causing a change in an amino acid in the nerve growth factor ([NGF]) gene, and based on this, it is also known as 104C>T or Ala35Val. The more common (C) allele encodes the alanine (Ala).
A study of 337 (age: 39.2 +/- 14.6 years) unrelated subjects of German descent found a significant (p=0.011) gender-dependent effect of this SNP on anxiety related personality traits. rs6330(C;C) females had higher levels of trait anxiety than (C;T) or (T;T) females, while the opposite effect was seen in males.[PMID 18763222]
[PMID 22330829] Possible influence of a non-synonymous polymorphism located in the NGF precursor on susceptibility to late-onset Alzheimer's disease and mild cognitive impairment.
[PMID 17192954] An investigation of the neurotrophic factor genes GDNF, NGF, and NT3 in susceptibility to ADHD.
[PMID 17212826
] TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach.
[PMID 18520591] Sequence variants in host cell factor C1 are associated with Meniere's disease.
[PMID 19063739] Genomic NGFB variation and multiple sclerosis in a case control study.
[PMID 23195334] Neurotrophin serum concentrations and polymorphisms of neurotrophins and their receptors in children with asthma
[PMID 23772677] Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information.
[PMID 25162994] Sex-Specific Association Between Nerve Growth Factor Polymorphism and Cardiac Vagal Modulation
[PMID 26579581] Genetic and environmental predictors of chronic kidney disease in patients with type 2 diabetes and diabetic foot ulcer: a pilot study
[PMID 28413930] Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in Children.
| ClinVar | |
|---|---|
| Risk | Rs6330(T;T) |
| Alt | Rs6330(T;T) |
| Reference | Rs6330(C;C) |
| Significance | Non-pathogenic |
| Disease | Congenital sensory neuropathy with selective loss of small myelinated fibers |
| Variation | info |
| Gene | NGF |
| CLNDBN | Congenital sensory neuropathy with selective loss of small myelinated fibers |
| Reversed | 1 |
| HGVS | NC_000001.10:g.115829313G>A |
| CLNSRC | |
| CLNACC | RCV000268865.1, |
