rs6427528

plus

Geno	Mag	Summary
(A;A)	1.5	for rheumatoid arthritis patients, better response to etanercept treatment
(A;G)	1.5	for rheumatoid arthritis patients, better response to etanercept treatment
(G;G)	0	common

Reference

GRCh38 38.1/141

Chromosome

1

Position

160546518

Gene	CD84, LOC105371468

is a	snp
is	mentioned by
dbSNP	rs6427528
dbSNP (classic)	rs6427528
ClinGen	rs6427528
ebi	rs6427528
HLI	rs6427528
Exac	rs6427528
Gnomad	rs6427528
Varsome	rs6427528
LitVar	rs6427528
Map	rs6427528
PheGenI	rs6427528
Biobank	rs6427528
1000 genomes	rs6427528
hgdp	rs6427528
ensembl	rs6427528
geneview	rs6427528
scholar	rs6427528
google	rs6427528
pharmgkb	rs6427528
gwascentral	rs6427528
openSNP	rs6427528
23andMe	rs6427528
SNPshot	rs6427528
SNPdbe	rs6427528
MSV3d	rs6427528
GWAS Ctlg	rs6427528

GMAF

0.1974

Max Magnitude

1.5

rs6427528 is a SNP in the chromosome 1q23 region apparently located near enough to the CD84 locus to affect it's expression.

A GWAS study of 2,700+ rheumatoid arthritis (RA) patients treated with one of three anti-TNF drugs found that rs6427528(A) carriers had higher CD84 expression and responded better to etanercept treatment. The effect was statistically significant but not that large in magnitude, totaling 2.6% of the variance in response to etanercept treatment. The result was seen in European (Caucasian) patients, but perhaps due to small patient numbers, was not statistically supported in Japanese patients.[PMID 23555300 ]

?

(A;A) (A;G) (G;G)

28

GWAS snp
PMID	[PMID 23555300 ]
Trait	Response to anti-TNF treatment in rheumatoid arthritis
Title	Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.
Risk Allele	A
P-val	2E-6
Odds Ratio	NR NR