||Highest adiponectin levels, presumably much lower obesity
||Slightly higher adiponectin levels, presumably lower obesity
||lowest adiponectin levels, presumably less lean
[PMID 23351195] A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome. The study used data from three western Australian cohorts, the Busselton Population Health Survey (BHS), the Carotid Ultrasound Disease Assessment Study (CUDAS) and the Fremantle Diabetes Study (FDS).
In the BHS, the AA allele had the highest (13.1 (11.7, 14.8)) adiponectin levels (serum adiponectin mg/L, labelled MM on the accompanying spreadsheet), followed by GA (11.4 (10.8, 11.9)
) and GG (10.5 (10.1, 10.9)).
In the CUDAS, the numbers were AA (11.9 (10.6, 13.3)), AG (11.0 (10.4, 11.5)
) and GG (10.1 (9.6, 10.5)).
In the FDS, the numbers were AA (8.0 (7.0, 9.2)), AG (7.1 (6.7, 7.5)) and GG (7.0 (6.6, 7.3)).
Other studies have suggested that higher adiponectin levels lead to leaner waistlines.
[PMID 18776141] Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.
[PMID 20011104] A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
[PMID 23274890] Evidence of a causal relationship between adiponectin levels and insulin sensitivity: a Mendelian randomization study.