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rs6444175

From SNPedia
Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) Highest adiponectin levels, presumably much lower obesity
(A;G) Slightly higher adiponectin levels, presumably lower obesity
(G;G) lowest adiponectin levels, presumably less lean
ReferenceGRCh38 38.1/141
Chromosome3
Position186861955
is asnp
is mentioned by
dbSNPrs6444175
dbSNP (old)rs6444175
ClinGenrs6444175
ebirs6444175
HLIrs6444175
Exacrs6444175
Gnomadrs6444175
Varsomers6444175
Maprs6444175
PheGenIrs6444175
Biobankrs6444175
1000 genomesrs6444175
hgdprs6444175
ensemblrs6444175
gopubmedrs6444175
geneviewrs6444175
scholarrs6444175
googlers6444175
pharmgkbrs6444175
gwascentralrs6444175
openSNPrs6444175
23andMers6444175
23andMe allrs6444175
SNP Nexus

SNPshotrs6444175
SNPdbers6444175
MSV3drs6444175
GWAS Ctlgrs6444175
GMAF0.2952
Max Magnitude
? (A;A) (A;G) (G;G) 28
Adiponectin Levels


[PMID 23351195OA-icon.png] A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome. The study used data from three western Australian cohorts, the Busselton Population Health Survey (BHS), the Carotid Ultrasound Disease Assessment Study (CUDAS) and the Fremantle Diabetes Study (FDS). In the BHS, the AA allele had the highest (13.1 (11.7, 14.8)) adiponectin levels (serum adiponectin mg/L, labelled MM on the accompanying spreadsheet), followed by GA (11.4 (10.8, 11.9) ) and GG (10.5 (10.1, 10.9)). In the CUDAS, the numbers were AA (11.9 (10.6, 13.3)), AG (11.0 (10.4, 11.5) ) and GG (10.1 (9.6, 10.5)). In the FDS, the numbers were AA (8.0 (7.0, 9.2)), AG (7.1 (6.7, 7.5)) and GG (7.0 (6.6, 7.3)). Other studies have suggested that higher adiponectin levels lead to leaner waistlines.


[PMID 18776141OA-icon.png] Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.


[PMID 20011104OA-icon.png] A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.


[PMID 23274890OA-icon.png] Evidence of a causal relationship between adiponectin levels and insulin sensitivity: a Mendelian randomization study.