|0.43x decreased risk for esophageal cancer
|0.58x decreased risk for esophageal cancer
|MIR3184, MIR423, NSRP1
A study of 346 Caucasians with esophageal cancer found that compared with the homozygous wild-type genotype of rs6505162, individuals with the heterozygous and homozygous variant genotype had a significantly reduced esophageal cancer risk with odds ratios of 0.58 (CI: 0.41-0.82) and 0.43 (CI: 0.27-0.68), respectively. After stratifying by gender, smoking, and age, the authors discovered that the protective effect was significant only for individuals under 64 years of age, regardless of sex or whether they smoked. Other unfavorable genotypes (ie SNPs) were also identified that were not as significant as rs6505162, and the overall risk of esophageal cancer increased with increasing numbers of unfavorable SNPs.10.1158/1940-6207.CAPR-08-0135 [PMID 19138993]
|snp near microRNA
discussed in nature
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