rs659366

Orientation

plus

Stabilized

plus

Make rs659366(C;C)

Make rs659366(C;T)

Make rs659366(T;T)

Reference

GRCh38 38.1/141

Chromosome

11

Position

73983709

Gene

UCP2

is a	snp
is	mentioned by
dbSNP	rs659366
dbSNP (classic)	rs659366
ClinGen	rs659366
ebi	rs659366
HLI	rs659366
Exac	rs659366
Gnomad	rs659366
Varsome	rs659366
LitVar	rs659366
Map	rs659366
PheGenI	rs659366
Biobank	rs659366
1000 genomes	rs659366
hgdp	rs659366
ensembl	rs659366
geneview	rs659366
scholar	rs659366
google	rs659366
pharmgkb	rs659366
gwascentral	rs659366
openSNP	rs659366
23andMe	rs659366
SNPshot	rs659366
SNPdbe	rs659366
MSV3d	rs659366
GWAS Ctlg	rs659366

GMAF

0.4155

Max Magnitude

0

?	(C;C) (C;T) (T;T)	28

[PMID 19387457] Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases

OMIM	601693
Desc	UNCOUPLING PROTEIN 2; UCP2
Variant
Related	also

[PMID 19769793] Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: The Finnish Diabetes Prevention Study

OMIM	601693
Desc
Variant	0001
Related	also

[PMID 21883184] Polymorphisms of the UCP2 gene are associated with body fat distribution and risk of abdominal obesity in Spanish population

[PMID 22241057] Variation in The Uncoupling Protein 2 and 3 Genes and Human Performance

[PMID 16046815] Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes.

[PMID 17570749] Genetic prediction of future type 2 diabetes.

[PMID 17701054] Interaction between the UCP2-866G/A, mtDNA 10398G/A and PGC1alpha p.Thr394Thr and p.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population.

[PMID 17870627] Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents.

[PMID 19406964] Association of genetic variants with chronic kidney disease in Japanese individuals.

[PMID 19681913] Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus.

[PMID 20145583] Interaction between the UCP2 -866 G>A polymorphism, diabetes, and beta-blocker use among patients with acute coronary syndromes.

[PMID 20359253] Effect of the common -866G/A polymorphism of the uncoupling protein 2 gene on weight loss and body composition under sibutramine therapy in an obese Taiwanese population.

[PMID 22349573] The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.

[PMID 22533685] Uncoupling protein 2 gene polymorphisms are associated with obesity

[PMID 23639961] Uncoupling protein 2 -866G/A and uncoupling protein 3 -55C/T polymorphisms in young South African Indian coronary artery disease patients

[PMID 23826253] Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study

[PMID 25396419] Investigation of Variants in UCP2 in Chinese Type 2 Diabetes and Diabetic Retinopathy

ClinVar
Risk	rs659366(T;T)
Alt	rs659366(T;T)
Reference	rs659366(C;C)
Significance	Other
Disease	Body mass index quantitative trait locus 4
Variation	info
Gene	UCP2
CLNDBN	Body mass index quantitative trait locus 4
Reversed	0
HGVS	NC_000011.9:g.73694754C>T
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000023142.3,

[PMID 26402942] [The study of the association of polymorphism rs659366 gene UCP2 c obesity and type 2 diabetes among residents of the Moscow Region]

[PMID 27615599] Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes.

[PMID 30393491] Association of common polymorphisms in the VEGFA and SIRT1 genes with type 2 diabetes-related traits in Mexicans.

[PMID 30444569] Genetic determinants of steatosis and fibrosis progression in pediatric non-alcoholic fatty liver disease.