rs664143

minus

Geno	Mag	Summary
(C;C)	0	normal
(C;T)	2.5	Higher risk for number of cancers
(T;T)	2.5	Higher risk for number of cancers

Reference

GRCh38 38.1/141

Chromosome

11

Position

108354934

Gene	ATM, C11orf65

is a	snp
is	mentioned by
dbSNP	rs664143
dbSNP (classic)	rs664143
ClinGen	rs664143
ebi	rs664143
HLI	rs664143
Exac	rs664143
Gnomad	rs664143
Varsome	rs664143
LitVar	rs664143
Map	rs664143
PheGenI	rs664143
Biobank	rs664143
1000 genomes	rs664143
hgdp	rs664143
ensembl	rs664143
geneview	rs664143
scholar	rs664143
google	rs664143
pharmgkb	rs664143
gwascentral	rs664143
openSNP	rs664143
23andMe	rs664143
SNPshot	rs664143
SNPdbe	rs664143
MSV3d	rs664143
GWAS Ctlg	rs664143

GMAF

0.404

Max Magnitude

2.5

?

(C;C) (C;T) (T;T)

28

600+ Korean lung cancer patients were part of a study that concluded that the rs664143(T) allele, as oriented vis-a-vis dbSNP, located in the ATM gene and also known as IVS62+60G>A, was associated with increased risk, with an odds ratio of 1.68 (CI: 1.1-2.1, p<0.05).[PMID 16497724]

In a study of 119 American patients with potentially resectable pancreatic cancer, the rs664143(C) allele was associated with poorer overall survival (ie response) to combined gerncitabine radiation therapy. Also, as 1 of 3 SNPs its risk allele is associated with poorer overall survival for pancreatic cancer patients being treated with combined gerncitabine radiation therapy; median overall survival times of 31.0, 16.2, and 10.5 months were calculated for pancreatic cancer patients carrying < or = 1, 2, and 3 risk alleles from rs664143(C), rs2227928(C), and rs521102(T;T), respectively (P=0.004). [PMID 18381943 ]

[PMID 21058196] Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk

[PMID 22203481] Association between ATM polymorphisms and cancer risk: a meta-analysis

[PMID 12466288 ] Haplotype and linkage disequilibrium architecture for human cancer-associated genes.

[PMID 17132159 ] Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.

[PMID 17151932] Genetic variation in p53 and ATM haplotypes and risk of glioma and meningioma.

[PMID 17431766] Two-stage case-control study of common ATM gene variants in relation to breast cancer risk.

[PMID 19115993 ] Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population.

[PMID 19536092 ] Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.

[PMID 19584272 ] Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.

[PMID 25196645] Single nucleotide polymorphisms of ataxia telangiectasia mutated and the risk of papillary thyroid carcinoma