rs66698963

Orientation

plus

Stabilized

plus

Make rs66698963(-;-)

Make rs66698963(-;ACTTCTCCCTGCCTCCCCAGGG)

Make rs66698963(ACTTCTCCCTGCCTCCCCAGGG;ACTTCTCCCTGCCTCCCCAGGG)

Reference

GRCh38.p2 38.2/146

Chromosome

11

Position

61835065

Gene

FADS2

is a	snp
is	mentioned by
dbSNP	rs66698963
dbSNP (classic)	rs66698963
ClinGen	rs66698963
ebi	rs66698963
HLI	rs66698963
Exac	rs66698963
Gnomad	rs66698963
Varsome	rs66698963
LitVar	rs66698963
Map	rs66698963
PheGenI	rs66698963
Biobank	rs66698963
1000 genomes	rs66698963
hgdp	rs66698963
ensembl	rs66698963
geneview	rs66698963
scholar	rs66698963
google	rs66698963
pharmgkb	rs66698963
gwascentral	rs66698963
openSNP	rs66698963
23andMe	rs66698963
SNPshot	rs66698963
SNPdbe	rs66698963
MSV3d	rs66698963
GWAS Ctlg	rs66698963

Max Magnitude

0

[PMID 27188529] Basal plasma phospholipid arachidonic acid (ARA) status was 8% greater in rs66698963 I/I compared with D/D individuals, consistent with previous in vitro data suggesting that the insertion allele enhances n-6 long-chain PUFA synthesis and may confer an adaptive advantage in South Asians (and other populations having a primarily vegetarian diet).

http://www.eurekalert.org/pub_releases/2016-03/mbae-aww032416.php and http://mbe.oxfordjournals.org/content/early/2016/03/09/molbev.msw049.abstract if they stray from a balanced omega-6 to omega-3 diet -- may make people more susceptible to inflammation, and by association, increased risk of heart disease and colon cancer.

ClinVar
Risk	rs66698963(-;-) Rs66698963(CTCCCTGCCTCCCCAGGGACTT;CTCCCTGCCTCCCCAGGGACTT)
Alt	rs66698963(-;-) Rs66698963(CTCCCTGCCTCCCCAGGGACTT;CTCCCTGCCTCCCCAGGGACTT)
Reference	rs66698963(ACTTCTCCCTGCCTCCCCAGGG;ACTTCTCCCTGCCTCCCCAGGG)
Significance	Untested
Disease	not provided
Variation	info
Gene	FADS2
CLNDBN	not provided
Reversed	0
HGVS	NC_000011.9:g.61602537_61602558del22
CLNSRC
CLNACC	RCV000149463.1,