| Geno
|
Mag
|
Summary
|
| (A;A)
|
1
|
Normal risk of developing restless legs syndrome
|
| (A;G)
|
1.5
|
Slightly increased risk of developing restless legs syndrome
|
| (G;G)
|
2
|
Increased risk of developing restless legs syndrome
|
rs6710341, a SNP located in the MEIS1 gene, has been linked to restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.96 (CI: 0.77-1.17) for the (G) risk allele. [PMID 17637780]
The association from this region that gives the highest association to restless legs syndrome, however, is a haplotype consisting of the rs6710341(A) and rs12469063(G) alleles. This haplotype gives rise to an odds ratio of 2.75 (CI: 2.23-3.41). [PMID 17637780]
[PMID 19223043] Exploring the genetic link between RLS and ADHD
[PMID 19279021
] Replication of restless legs syndrome loci in three European populations.
] Replication of restless legs syndrome loci in three European populations.
