rs6742078

plus

Geno	Mag	Summary
(G;G)	0	normal
(G;T)
(T;T)	2.1	+16% bilirubin levels increased risk of gallstones

Reference

GRCh38 38.1/141

Chromosome

2

Position

233763993

Gene	UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10

is a	snp
is	mentioned by
dbSNP	rs6742078
dbSNP (classic)	rs6742078
ClinGen	rs6742078
ebi	rs6742078
HLI	rs6742078
Exac	rs6742078
Gnomad	rs6742078
Varsome	rs6742078
LitVar	rs6742078
Map	rs6742078
PheGenI	rs6742078
Biobank	rs6742078
1000 genomes	rs6742078
hgdp	rs6742078
ensembl	rs6742078
geneview	rs6742078
scholar	rs6742078
google	rs6742078
pharmgkb	rs6742078
gwascentral	rs6742078
openSNP	rs6742078
23andMe	rs6742078
SNPshot	rs6742078
SNPdbe	rs6742078
MSV3d	rs6742078
GWAS Ctlg	rs6742078

GMAF

0.3035

Max Magnitude

2.1

?

(G;G) (G;T) (T;T)

28

GWAS snp
PMID	[PMID 19414484 ]
Trait	Serum bilirubin levels
Title	Genome-wide association meta-analysis for total serum bilirubin levels
Risk Allele	T
P-val	0
Odds Ratio	0.23 [0.21-0.25] umol/l increase in log(tbil)

[PMID 20837016] Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition

OMIM	191740
Desc	UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1
Variant
Related	also

OMIM	191740
Desc
Variant	0025
Related	also

OMIM	601816
Desc
Variant
Related	also

[PMID 21412181] Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab

GWAS snp
PMID	[PMID 22511988 ]
Trait
Title	A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.
Risk Allele	T
P-val	2E-23
Odds Ratio	0.3358 None

[PMID 19223546 ] Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer.

[PMID 19482841 ] Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis.

[PMID 23753274] Extreme bilirubin levels as a causal risk factor for symptomatic gallstone disease

[PMID 23371916] A Genome-Wide Association Study for Serum Bilirubin Levels and Gene-Environment Interaction in a Chinese Population

[PMID 22805420] Genetically elevated bilirubin and risk of ischaemic heart disease: three Mendelian randomization studies and a meta-analysis

ClinVar
Risk	Rs6742078(T;T)
Alt	Rs6742078(T;T)
Reference	Rs6742078(G;G)
Significance	Other
Disease	Bilirubin
Variation	info
Gene	UGT1A5 UGT1A9 UGT1A3 UGT1A6 UGT1A4 UGT1A1 UGT1A8 UGT1A10 UGT1A7
CLNDBN	Bilirubin, serum level of, quantitative trait locus 1
Reversed	0
HGVS	NC_000002.11:g.234672639G>T
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000013083.4,

GWAS snp
PMID	[PMID 20639394 ]
Trait	Bilirubin levels
Title	Genome-wide association of serum bilirubin levels in Korean population.
Risk Allele
P-val	1E-158
Odds Ratio	.18 [NR] bilirubin level increase