rs6910071
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | normal |
| (A;G) | ||
| (G;G) | 2 | 6x higher risk of rheumatoid arthritis |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 32315077 |
| Gene | C6orf10, LOC101929163 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6910071 |
| dbSNP (classic) | rs6910071 |
| ClinGen | rs6910071 |
| ebi | rs6910071 |
| HLI | rs6910071 |
| Exac | rs6910071 |
| Gnomad | rs6910071 |
| Varsome | rs6910071 |
| LitVar | rs6910071 |
| Map | rs6910071 |
| PheGenI | rs6910071 |
| Biobank | rs6910071 |
| 1000 genomes | rs6910071 |
| hgdp | rs6910071 |
| ensembl | rs6910071 |
| geneview | rs6910071 |
| scholar | rs6910071 |
| rs6910071 | |
| pharmgkb | rs6910071 |
| gwascentral | rs6910071 |
| openSNP | rs6910071 |
| 23andMe | rs6910071 |
| SNPshot | rs6910071 |
| SNPdbe | rs6910071 |
| MSV3d | rs6910071 |
| GWAS Ctlg | rs6910071 |
| GMAF | 0.1309 |
| Max Magnitude | 2 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
This SNP, along with SNPs rs660895 and rs3817964, is a tag SNP for the HLA-DRB1*0401 allele.
The HLA-DRB1*0401 allele has been associated with higher risk for rheumatoid arthritis, and in particular, rheumatoid vasculitis. The association is seen particularly for individuals carrying two copies of, i.e. homozygous for, the allele. The reported odds ratio for rs6910071(G;G) homozygotes is 6.2 (CI: 1.01 - 37.9). [PMID 15529352]
The risk for rheumatoid arthritis may be higher for individuals carrying one copy (one "dose") of the HLA-DRB1*0401 allele, if they also carry a different HLA-DRB1 risk allele. In particular, *0401/*0404 individuals are reported to have an odds ratio for rheumatoid vasculitis of 4.1 (CI: 1.1 - 16.2), and *0401/*0101 individuals have an odds ratio of 4.0 (CI: 1.4 - 11.6). [PMID 15529352]
| GWAS snp | |
|---|---|
| PMID | [PMID 20453842 ]
|
| Trait | Rheumatoid arthritis |
| Title | Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lock |
| Risk Allele | G |
| P-val | 0 |
| Odds Ratio | 2.88 [2.73-3.03] |
[PMID 24270849] rs6910071 was found to be associated with rheumatoid arthritis based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs.
[PMID 15747258] A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms.
[PMID 20017995] A principal-components-based clustering method to identify multiple variants associated with rheumatoid arthritis and arthritis-related autoantibodies.
[PMID 20018015] Elastic-net regularization approaches for genome-wide association studies of rheumatoid arthritis.
[PMID 20018025] Genome-wide analysis of haplotype interaction for the data from the North American Rheumatoid Arthritis Consortium.
[PMID 20018053] A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 tests.
[PMID 20018067] A two-stage search strategy for detecting multiple loci associated with rheumatoid arthritis.
[PMID 20018081] Assessment of gene-covariate interactions by incorporating covariates into association mapping.
[PMID 21383967] Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
[PMID 23223422] Identification of the NF-kappaB activating protein-like locus as a risk locus for rheumatoid arthritis.
| GWAS snp | |
|---|---|
| PMID | [PMID 24449572]
|
| Trait | Rheumatoid arthritis |
| Title | Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. |
| Risk Allele | |
| P-val | 2E-124 |
| Odds Ratio | 2.30 [2.14-2.46] |
