rs7192
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | common/normal |
| (G;T) | 1.7 | 1.7x increased risk for developing a peanut allergy |
| (T;T) | 3 | 3x higher risk for developing a peanut allergy |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 32443869 |
| Gene | HLA-DRA |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7192 |
| dbSNP (classic) | rs7192 |
| ClinGen | rs7192 |
| ebi | rs7192 |
| HLI | rs7192 |
| Exac | rs7192 |
| Gnomad | rs7192 |
| Varsome | rs7192 |
| LitVar | rs7192 |
| Map | rs7192 |
| PheGenI | rs7192 |
| Biobank | rs7192 |
| 1000 genomes | rs7192 |
| hgdp | rs7192 |
| ensembl | rs7192 |
| geneview | rs7192 |
| scholar | rs7192 |
| rs7192 | |
| pharmgkb | rs7192 |
| gwascentral | rs7192 |
| openSNP | rs7192 |
| 23andMe | rs7192 |
| SNPshot | rs7192 |
| SNPdbe | rs7192 |
| MSV3d | rs7192 |
| GWAS Ctlg | rs7192 |
| GMAF | 0.3678 |
| Max Magnitude | 3 |
rs7192, also known as Leu242Val or L242V, is a SNP in the HLA-DRA gene on chromosome 6.
A study of several thousand children and their parents, most with food allergies, concluded that two SNPs, rs7192 and rs9275596, are associated with increased susceptibility to developing a peanut allergy in populations of European ancestry. The odds ratio reported for rs7192(T) were 1.7 (p=10e-8).[PMID 25710614
]
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
Detecting significant single-nucleotide polymorphisms in a rheumatoid arthritis study using random forests[PMID 20018063]
[PMID 20587610] Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection
| GWAS snp | |
|---|---|
| PMID | [PMID 22541561]
|
| Trait | |
| Title | A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia. |
| Risk Allele | T |
| P-val | 0.000003 |
| Odds Ratio | 1.2900 None |
[PMID 18204098] Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
[PMID 19143810] Haplotype-based search for SNPs associated with differential type 1 diabetes risk among chromosomes carrying a specific HLA DRB1-DQA1-DQB1 haplotype.
[PMID 20018067] A two-stage search strategy for detecting multiple loci associated with rheumatoid arthritis.
[PMID 20018081] Assessment of gene-covariate interactions by incorporating covariates into association mapping.
[PMID 22201026] Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet's disease.
[PMID 23200760] Pathway analysis of genome-wide association study on asthma
[PMID 23053960] Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.
[PMID 23238918] Genome-wide pathway analysis of a genome-wide association study on multiple sclerosis.
