rs7305115
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | Individuals showed a significantly lower risk of suicide behavior than those with the A/G or G/G genotype |
| (A;G) | risk of suicide behavior | |
| (G;G) | risk of suicide behavior |
| Reference | GRCh38 38.1/141 |
| Chromosome | 12 |
| Position | 71979082 |
| Gene | TPH2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7305115 |
| dbSNP (classic) | rs7305115 |
| ClinGen | rs7305115 |
| ebi | rs7305115 |
| HLI | rs7305115 |
| Exac | rs7305115 |
| Gnomad | rs7305115 |
| Varsome | rs7305115 |
| LitVar | rs7305115 |
| Map | rs7305115 |
| PheGenI | rs7305115 |
| Biobank | rs7305115 |
| 1000 genomes | rs7305115 |
| hgdp | rs7305115 |
| ensembl | rs7305115 |
| geneview | rs7305115 |
| scholar | rs7305115 |
| rs7305115 | |
| pharmgkb | rs7305115 |
| gwascentral | rs7305115 |
| openSNP | rs7305115 |
| 23andMe | rs7305115 |
| SNPshot | rs7305115 |
| SNPdbe | rs7305115 |
| MSV3d | rs7305115 |
| GWAS Ctlg | rs7305115 |
| GMAF | 0.4734 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 17011525] Effect of rs7305115 on susceptibility to suicide.
[PMID 19763617] Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease
[PMID 20738857
] Effect of Tryptophan Hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression
[PMID 21620479] Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population
[PMID 21969281] Influence of birth weight on internalizing traits modulated by serotonergic genes
[PMID 17649681] [A case-control study on the risk factors for attempted suicide in patients with major depression].
[PMID 18439448] Stress, genes and the biology of suicidal behavior.
[PMID 18698231] Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.
[PMID 19693267] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
[PMID 20126463] Alternative splicing and extensive RNA editing of human TPH2 transcripts.
[PMID 20403506] Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study.
[PMID 20938755] Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21937687] Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.
[PMID 22655589] Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.
[PMID 23628433] Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.
[PMID 25214390] Interaction among childhood trauma and functional polymorphisms in the serotonin pathway moderate the risk of depressive disorders
[PMID 26028568] Association analysis of TPH-1 and TPH-2 genes with suicidal behavior in patients with attempted suicide in Mexican population
[PMID 26057341] Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population
[PMID 26232682] Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms
| ClinVar | |
|---|---|
| Risk | Rs7305115(G;G) |
| Alt | Rs7305115(G;G) |
| Reference | Rs7305115(A;A) |
| Significance | Probable-non-pathogenic |
| Disease | Tryptophan 5-monooxygenase deficiency |
| Variation | info |
| Gene | TPH2 |
| CLNDBN | Tryptophan 5-monooxygenase deficiency |
| Reversed | 0 |
| HGVS | NC_000012.11:g.72372862A>G |
| CLNSRC | |
| CLNACC | RCV000305884.1, |
