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rs7439293

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) increased risk of coronary heart disease; better response to statins
(A;G) increased risk of coronary heart disease; better response to statins
(G;G) normal
ReferenceGRCh38 38.1/141
Chromosome4
Position168756335
GenePALLD
is asnp
is mentioned by
dbSNPrs7439293
dbSNP (classic)rs7439293
ClinGenrs7439293
ebirs7439293
HLIrs7439293
Exacrs7439293
Gnomadrs7439293
Varsomers7439293
LitVarrs7439293
Maprs7439293
PheGenIrs7439293
Biobankrs7439293
1000 genomesrs7439293
hgdprs7439293
ensemblrs7439293
geneviewrs7439293
scholarrs7439293
googlers7439293
pharmgkbrs7439293
gwascentralrs7439293
openSNPrs7439293
23andMers7439293
SNPshotrs7439293
SNPdbers7439293
MSV3drs7439293
GWAS Ctlgrs7439293
GMAF0.3329
Max Magnitude0
? (A;A) (A;G) (G;G) 28


rs7439293 is a SNP in the PALLD gene. The risk allele in terms of heart disease is rs7439293(A).

This SNP is one of the 5 used by Celera's genetic risk score (GRS) for coronary heart disease (CHD).

For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.[PMID 18073581]




[PMID 18799872OA-icon.png] Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study.


[PMID 19752551OA-icon.png] Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry.


[PMID 21054356] Polymorphism of the palladin gene and cardiovascular outcome in patients with atherosclerosis.