rs2298566

plus

Geno	Mag	Summary
(A;A)	0	normal
(A;C)	2	increased risk of coronary heart disease; better response to statins
(C;C)		increased risk of coronary heart disease; better response to statins

Reference

GRCh38 38.1/141

Chromosome

11

Position

130880747

Gene

SNX19

is a	snp
is	mentioned by
dbSNP	rs2298566
dbSNP (classic)	rs2298566
ClinGen	rs2298566
ebi	rs2298566
HLI	rs2298566
Exac	rs2298566
Gnomad	rs2298566
Varsome	rs2298566
LitVar	rs2298566
Map	rs2298566
PheGenI	rs2298566
Biobank	rs2298566
1000 genomes	rs2298566
hgdp	rs2298566
ensembl	rs2298566
geneview	rs2298566
scholar	rs2298566
google	rs2298566
pharmgkb	rs2298566
gwascentral	rs2298566
openSNP	rs2298566
23andMe	rs2298566
SNPshot	rs2298566
SNPdbe	rs2298566
MSV3d	rs2298566
GWAS Ctlg	rs2298566

GMAF

0.2236

Max Magnitude

2

?

(A;A) (A;C) (C;C)

28

rs2298566 is a SNP in the SNX19 gene. The risk allele in terms of heart disease is rs2298566(C).

This SNP is one of the 5 used by Celera's genetic risk score (GRS) for coronary heart disease (CHD).

rs20455, in the KIF6 gene
rs3900940, in the MYH15 gene
rs7439293, in the PALLD gene
rs2298566, in the SNX19 gene
rs1010, in the VAMP8 gene

For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.[PMID 18073581]

[PMID 19752551 ] Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry.