rs749292
| Orientation | plus |
| Stabilized | plus |
| Make rs749292(A;A) |
| Make rs749292(A;G) |
| Make rs749292(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 15 |
| Position | 51266534 |
| Gene | CYP19A1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs749292 |
| dbSNP (classic) | rs749292 |
| ClinGen | rs749292 |
| ebi | rs749292 |
| HLI | rs749292 |
| Exac | rs749292 |
| Gnomad | rs749292 |
| Varsome | rs749292 |
| LitVar | rs749292 |
| Map | rs749292 |
| PheGenI | rs749292 |
| Biobank | rs749292 |
| 1000 genomes | rs749292 |
| hgdp | rs749292 |
| ensembl | rs749292 |
| geneview | rs749292 |
| scholar | rs749292 |
| rs749292 | |
| pharmgkb | rs749292 |
| gwascentral | rs749292 |
| openSNP | rs749292 |
| 23andMe | rs749292 |
| SNPshot | rs749292 |
| SNPdbe | rs749292 |
| MSV3d | rs749292 |
| GWAS Ctlg | rs749292 |
| GMAF | 0.4307 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 18667686
] rs749292(A) associated with ovarian cancer risk in a codominant model for all races combined [AG versus AA genotype: odds ratio (OR), 1.48 and 95% confidence interval (CI), 1.07-2.04); GG versus AA: OR, 1.87 (CI, 1.24-2.82); Ptrend =0.002].
[PMID 19124504] endometrial cancer
- rs749292(A) allele OR of 1.14, 95% confidence interval of 1.09-1.21, and P = 7.1 x 10(-7)
- rs727479(A) odds ratio per allele of 1.08, 95% confidence interval of 1.02-1.14, and P = 0.009
[PMID 19789370] CYP19A1 Genetic Variation in Relation to Prostate Cancer Risk and Circulating Sex Hormone Concentrations in Men from the Breast and Prostate Cancer Cohort Consortium
[PMID 16733710] Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families.
[PMID 16782804] Polymorphisms of estrogen-biosynthesis genes CYP17 and CYP19 may influence age at menarche: a genetic association study in Caucasian females.
[PMID 16949385] Aromatase gene (CYP 19) polymorphisms and endogenous androgen concentrations in a multiracial/multiethnic, multisite study of women at midlife.
[PMID 16949394] Cognitive functioning and sex steroid hormone gene polymorphisms in women at midlife.
[PMID 17002564] Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction.
[PMID 17325027] Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.
[PMID 18199708] Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study.
[PMID 18622258] Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women.
[PMID 18941913] Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer.
[PMID 19015200] Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.
[PMID 19064562] Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China.
[PMID 19630952] Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women.
[PMID 23129173] Plasma estrone sulfate concentrations and genetic variation at the CYP19A1 locus in postmenopausal women with early breast cancer treated with letrozole
[PMID 26463708] Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy
