rs7569963

plus

Geno	Mag	Summary
(G;G)	0

Make rs7569963(A;A)

Make rs7569963(A;G)

Reference

GRCh38 38.1/141

Chromosome

2

Position

207608460

Gene

METTL21A

is a	snp
is	mentioned by
dbSNP	rs7569963
dbSNP (classic)	rs7569963
ClinGen	rs7569963
ebi	rs7569963
HLI	rs7569963
Exac	rs7569963
Gnomad	rs7569963
Varsome	rs7569963
LitVar	rs7569963
Map	rs7569963
PheGenI	rs7569963
Biobank	rs7569963
1000 genomes	rs7569963
hgdp	rs7569963
ensembl	rs7569963
geneview	rs7569963
scholar	rs7569963
google	rs7569963
pharmgkb	rs7569963
gwascentral	rs7569963
openSNP	rs7569963
23andMe	rs7569963
SNPshot	rs7569963
SNPdbe	rs7569963
MSV3d	rs7569963
GWAS Ctlg	rs7569963

GMAF

0.1809

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

rs7569963 is directly adjacent to CREB1.

[PMID 17548750] Associated with significantly (p = 0.005) increased chance of suicide in a study of 1447 citalopram users (male only subgroup, 539 in total). Two haplotypes (see below) also showed significant association with suicidality in the male subgroup.

rs2709376(C),rs2253206(A),rs7569963(A),rs7594560(T),rs4675690(C) - common haplotype, reduced chance of suicide in males, p = 0.004
rs2709376(C),rs2253206(A),rs7569963(G),rs7594560(T),rs4675690(T) - increased chance of suicide in males, p = 0.009

[PMID 20643483] A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression.